ORIGIN AND TERMINATION OF HIPPOCAMPAL PERFORANT PATH IN RAT STUDIED BY SILVER IMPREGNATION
ORIGIN AND TERMINATION OF HIPPOCAMPAL PERFORANT PATH IN RAT STUDIED BY SILVER IMPREGNATION
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DOI：
10.1002/cne.901440206
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发表时间：
1972-01-01
影响因子：
2.5
通讯作者：
JEUNE, B
中科院分区：
文献类型：
--
作者：
HJORTHSIMONSEN, A;JEUNE, B
对大鼠海马区所谓的穿通通路的起源和终止进行了详细的研究。这条神经管将内嗅区与海马和齿状筋膜连接起来。在海马的所有背基底水平，终末区已被证明占据齿筋膜分子层的中部和海马子区CA 3的陷窝分子层的水平，该水平靠近放射层。齿状分子层的内外部、CA_1亚区的腔隙分子层及CA_3亚区的腔隙分子层的浅层仅含通道纤维。已发现穿通路径的起源于内嗅区的内侧部分，从最背侧到最腹侧水平。纤维至少部分地来自层I-III中的细胞。内嗅区外侧部分的病变不影响穿支通路。一个局部组织已被证明：病变背内嗅区引起终端退化的前喙（隔）部分的海马。腹侧损伤越多，海马体的尾侧（颞侧）节段的变性越大。先前对穿孔路径所经过的路线的描述已经得到证实。此外，海马和齿状筋膜的最吻侧部分的轴突已被证明在下托和CA 1的背侧和吻侧部分表面上形成半球内侧的暴露部分。
A detailed study of the origin and termination of the so-called perforant path of the hippocampal region has been made in the rat. This tract connects the entorhinal area with the hippocampus and the fascia dentata. At all dorso-basal levels of the hippocampus, the terminal field has been shown to occupy the middle part of the molecular layer of the fascia dentata and that level of the stratum lacunosum-moleculare of the hippocampal subfield CA3 which is close to the stratum radiatum. The outer and inner parts of the dentate molecular layer, the stratum lacunosum-moleculare of subfield CA1, and the superficial part of the latter layer in CA3 contained fibers en passage only. The origin of the perforant path has been found to be in the medial part of the entorhinal area, from the most dorsal to the most ventral levels. The fibers arise in part at least from cells in layers I—III. Lesions of the lateral part of the entorhinal area leave the perforant path unaffected. A topical organization has been demonstrated: Lesions dorsal in the entorhinal area evoke terminal degeneration in antero-rostral (septal) parts of the hippocampus only. More ventral lesions produce degeneration in increasingly caudal (temporal) segments of the hippocampus. Earlier descriptions of the route traversed by the perforant path have been confirmed. In addition, the axons to the most rostral parts of the hippocampus and fascia dentata have been shown to course superficially in the dorsal and rostral parts of the subiculum and CA1 which form an exposed part of the medial aspect of the hemisphere.