Expression of potassium channels in gerbil outer hair cells during development does not require neural induction
Expression of potassium channels in gerbil outer hair cells during development does not require neural induction
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DOI：
10.1016/s0165-3806(97)00120-x
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发表时间：
1997-10-20
期刊：
影响因子：
--
通讯作者：
Dallos, P
中科院分区：
文献类型：
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作者：
He, DZZ;Dallos, P
哺乳动物外毛细胞（OHCs）突触极中含有钙离子和钾离子通道。我们质疑OHCs钾电流的个体发生是否依赖于早期传入接触的神经诱导。通过记录在无传入神经支配的器官型培养中生长的OHCs的全细胞电流，我们发现ca激活的K通道在这些细胞中表达，这表明K通道的形成是一个内在的过程。(C) 1997爱思唯尔科学有限公司
Mammalian outer hair cells (OHCs) contain Ca and K channels in their synaptic pole. We questioned if the ontogeny of potassium currents of OHCs depends on the neural induction of early afferent contact. By recording whole-cell currents of OHCs grown in organotypic cultures deprived of afferent innervation, we show that a Ca-activated K channel is expressed in these cells, suggesting that the ontogeny of the K channel is an intrinsic process. (C) 1997 Elsevier Science B.V.