Effluent from drug manufactures contains extremely high levels of pharmaceuticals
Effluent from drug manufactures contains extremely high levels of pharmaceuticals
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DOI：
10.1016/j.jhazmat.2007.07.008
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发表时间：
2007-09-30
影响因子：
13.6
通讯作者：
Paxeus, Nicklas
中科院分区：
文献类型：
--
作者：
Larsson, D. G. Joakim;de Pedro, Cecilia;Paxeus, Nicklas
人们普遍认为，人类药物进入水生环境的主要途径是通过污水处理厂接收来自家庭和医院的废水。我们分析了废水处理厂的废水中的药物，该废水处理厂为印度海得拉巴附近的帕坦切鲁（Patancheru）约90家原料药制造商提供服务，该工厂是世界市场仿制药的主要生产基地。这些样本含有迄今为止所有废水中最高水平的药物。几种广谱抗生素的高水平引起了人们对耐药性发展的担忧。最丰富的药物，环丙沙星（高达31000微克/升）的浓度超过一些细菌的毒性水平超过1000倍。本研究的结果要求更加关注不同地区生产设施中活性药物成分的潜在释放。(C)2007 Elsevier B. V.保留所有权利。
It is generally accepted that the main route for human pharmaceuticals to the aquatic environment is via sewage treatment plants receiving wastewater from households and hospitals. We have analysed pharmaceuticals in the effluent from a wastewater treatment plant serving about 90 bulk drug manufacturers in Patancheru, near Hyderabad, India-a major production site of generic drugs for the world market. The samples contained by far the highest levels of pharmaceuticals reported in any effluent. The high levels of several broad-spectrum antibiotics raise concerns about resistance development. The concentration of the most abundant drug, ciprofloxacin (up to 3 1,000 mu g/L) exceeds levels toxic to some bacteria by over 1000-fold. The results from the present study call for an increased focus on the potential release of active pharmaceutical ingredients from production facilities in different regions. (C) 2007 Elsevier B.V. All rights reserved.