Effects of bicuculline on inspiratory activities in piglets.
Effects of bicuculline on inspiratory activities in piglets.
复制标题
荷包牡丹碱对仔猪呼吸活动的影响。
DOI：
10.1016/0006-8993(94)90222-4
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发表时间：
1994
期刊：
影响因子：
2.9
通讯作者：
Sica,AL
中科院分区：
文献类型：
--
作者：
Steele,AM;Siddiqi,ZA;Sica,AL
用GABA受体拮抗剂荷包牡丹碱评价发育猪α受体亚型对γ-氨基丁酸识别位点的拮抗作用。荷包牡丹碱的作用是增加了膈神经和舌下神经的放电幅度。荷包牡丹碱对放电幅度的这种影响在自动功率谱中表现为位于中频(10-50赫兹)频段的峰值功率增加。更重要的是，荷包牡丹碱给药增加了相干性估计，证明了GABA对输出在10-50赫兹频段的中央模式生成器的影响。
Antagonism of the α receptor sub-type at γ-aminobutyric acid (GABA) recognition sites in developing pigs was evaluated using the GABAAreceptor antagonist bicuculline. The effect of bicuculline infusions was to produce an increase of phrenic and hypoglossal discharge amplitudes. This bicuculline-induced effect on discharge amplitude was manifested in autopower spectra as an increase in the power of peaks located in the medium-frequency (10–50 Hz) band. More importantly, coherence estimates were increased by bicuculline administration demonstrating GABA-mediated influences on a central pattern generator with output in the 10–50 Hz band.