Structural and Functional Properties of Deep Abdominal Subcutaneous Adipose Tissue Explain Its Association With Insulin Resistance and Cardiovascular Risk in Men
Structural and Functional Properties of Deep Abdominal Subcutaneous Adipose Tissue Explain Its Association With Insulin Resistance and Cardiovascular Risk in Men
复制标题
DOI：
10.2337/dc13-1353
复制
发表时间：
2014-03-01
期刊：
影响因子：
16.2
通讯作者：
Karpe, Fredrik
中科院分区：
文献类型：
--
作者：
Marinou, Kyriakoula;Hodson, Leanne;Karpe, Fredrik
脂肪分布是解释肥胖代谢异质性的重要变量。腹部皮下脂肪组织（SAT）被斯卡帕筋膜分为深层皮下脂肪组织（dSAT）和浅层皮下脂肪组织（sSAT）层。本研究旨在表征两个SAT层之间的功能差异，探索其相对贡献代谢性状和心血管风险（CVR）profile.RESEARCH设计和METHODSWe招募了371高加索人连续从当地随机，人口为基础的筛选项目在牛津和25个亚洲印度人从当地社区。通过超声（US）确定SAT层的深度，并在US引导下对43名高加索人进行脂肪组织（AT）活检。内脏脂肪组织（VAT）质量通过双能X线吸收扫描进行定量分析。两个种族中的TSMale肥胖症的特征是dSAT不成比例的扩张，这与VAT质量密切相关。dSAT深度是男性整体胰岛素抵抗（IR; IR的稳态模型评估）、肝脏特异性IR（胰岛素样生长因子结合蛋白-1）和Fragrance风险评分的强预测因子，与其他肥胖指标无关。此外，dSAT具有较高的促炎基因、脂肪生成基因和脂解基因的表达，并且含有较高比例的饱和脂肪酸。有小脂肪细胞的比例增加dSAT.CONCLUSIONSSAT是异质性的，dSAT扩展比sSAT增加肥胖的高加索男性（也证实在亚洲印度人）。其扩张与CVR增加相关，与其他肥胖指标无关，并且其生物学特性提示较高的代谢活性有助于整体IR。
OBJECTIVEFat distribution is an important variable explaining metabolic heterogeneity of obesity. Abdominal subcutaneous adipose tissue (SAT) is divided by the Scarpa's fascia into a deep subcutaneous adipose tissue (dSAT) and a superficial subcutaneous adipose tissue (sSAT) layer. This study sought to characterize functional differences between the two SAT layers to explore their relative contribution to metabolic traits and cardiovascular risk (CVR) profile.RESEARCH DESIGN AND METHODSWe recruited 371 Caucasians consecutively from a local random, population-based screening project in Oxford and 25 Asian Indians from the local community. The depth of the SAT layers was determined by ultrasound (US), and adipose tissue (AT) biopsies were performed under US guidance in a subgroup of 43 Caucasians. Visceral adipose tissue (VAT) mass was quantified by dual-energy X-ray absorptiometry scan.RESULTSMale adiposity in both ethnic groups was characterized by a disproportionate expansion of dSAT, which was strongly correlated with VAT mass. dSAT depth was a strong predictor of global insulin resistance (IR; homeostatic model assessment of IR), liver-specific IR (insulin-like growth factor binding protein-1), and Framingham risk score independently of other measures of adiposity in men. Moreover, dSAT had higher expression of proinflammatory, lipogenic, and lipolytic genes and contained higher proportions of saturated fatty acids. There was increased proportion of small adipocytes in dSAT.CONCLUSIONSSAT is heterogeneous; dSAT expands disproportionally more than sSAT with increasing obesity in Caucasian males (confirmed also in Asian Indians). Its expansion is related to increased CVR independent of other adiposity measures, and it has biological properties suggestive of higher metabolic activity contributing to global IR.