Initial Experience With Low-Dose 18F-Fluorodeoxyglucose Positron Emission Tomography/Magnetic Resonance Imaging With Deep Learning Enhancement.
Initial Experience With Low-Dose 18F-Fluorodeoxyglucose Positron Emission Tomography/Magnetic Resonance Imaging With Deep Learning Enhancement.
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DOI：
10.1097/rct.0000000000001174
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发表时间：
2021-07-01
影响因子：
1.3
通讯作者：
McMillan AB
中科院分区：
文献类型：
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作者：
Park CJ;Chen W;Pirasteh A;Kim DH;Perlman SB;Robbins JB;McMillan AB
为了证明深度学习增强（DLE）在实现诊断质量低剂量PET/MR方面的实用性。二十名患有已知克罗恩病的受试者在静脉注射约185 MBq的18 F-氟脱氧葡萄糖（FDG）后接受了同步PET/MR成像。生成五个图像集：（1）标准护理（参考），（2）低剂量（即使用20%的PET计数），（3）使用PET数据作为输入的DLE增强低剂量，（4）使用PET和MR数据作为输入的DLE增强低剂量，以及（5）不使用PET计数的DLE增强。图像集由专家阅片师通过定量指标和定性指标进行评价。尽管低剂量图像（系列2）和无PET数据输入的图像（系列5）是非诊断性的，但低剂量图像（系列3和4）的DLE增强实现了诊断质量图像，其在定性和定量方面的评分均优于参考图像（系列1）。DLE增强有可能使放射性示踪剂减少90%，同时获得诊断质量的图像。
To demonstrate the utility of deep-learning-enhancement (DLE) to achieve diagnostic quality low-dose PET/MR. Twenty subjects with known Crohn disease underwent simultaneous PET/MR imaging after intravenous administration of approximately 185 MBq of 18F-fluorodeoxyglucose (FDG). Five image sets were generated: (1) standard-of-care (reference), (2) low-dose (i.e. using 20% of PET counts), (3) DLE-enhanced low-dose using PET data as input, (4) DLE-enhanced low-dose using PET and MR data as input, and (5) DLE-enhanced using no PET counts. Image sets were evaluated by both quantitative metrics and qualitatively by expert readers. Although low-dose images (series 2) and images with no PET data input (series 5) were non-diagnostic, DLE enhancement of the low-dose images (series 3 and 4) achieved diagnostic quality images that scored more favorable than the reference (series 1), both qualitatively and quantitatively. DLE enhancement has the potential to enable a 90% reduction of radiotracer while achieving diagnostic quality images.