Applicator reconstruction in MRI 3D image-based dose planning of brachytherapy for cervical cancer
Applicator reconstruction in MRI 3D image-based dose planning of brachytherapy for cervical cancer
复制标题
DOI：
10.1016/j.radonc.2008.09.002
复制
发表时间：
2009-05-01
影响因子：
5.7
通讯作者：
Tanderup, Kari
中科院分区：
文献类型：
--
作者：
Haack, Soren;Nielsen, Soren Kynde;Tanderup, Kari
背景和目的：阐述一种基于MRI的宫颈癌近距离放射治疗中的敷贴器重建方法。材料和方法：将定制的含有硫酸铜溶液的塑料导管插入MR-CT兼容的敷贴器的源通道中：塑料和钛串联环敷置器以及钛针。在体模中对涂抹器进行CT和MR扫描，以准确地评估涂抹器的可见性和几何形状。对19例患者应用环形敷贴器(塑料14例，钛5例)的MR检查中的重建方法进行了评价。结果：在体模的T1加权图像上，14/14的临床应用中，可以在塑料涂敷器上看到导管。在T2加权图像上，导管看起来较弱，但在体模和13/14磁共振临床应用中仍可见。在钛敷贴器中，导管不能与敷贴器本身的器物分离。然而，这些伪影可以用于定位钛环敷贴器(5/5的临床应用)和针头(6/6的临床应用)。各方向观察者间差值的标准差均在2 mm以下。结论：基于MR成像的涂抹器三维重建可用于塑料和钛敷贴器的三维重建。事实证明，塑料敷贴器很适合于基于MRI的重建。为了提高钛敷贴器改造的实用性，开发MR敷贴器市场是必不可少的。在患者使用钛敷贴器之前，在1.5T磁共振下重建钛敷贴器和针需要在体模中进行几何评估。(C)2008爱思唯尔爱尔兰有限公司。保留所有权利。放射治疗和肿瘤学91(2009)187-193
Background and purpose: To elaborate a method for applicator reconstruction for MRI-based brachytherapy for cervical cancer.Materials and methods: Custom-made plastic catheters with a copper sulphate solution were made for insertion in the Source channels of MR-CT compatible applicators: plastic and titanium tandem ring applicators, and titanium needles. The applicators were CT and MR scanned in a phantom for accurate 3D assessment of applicator visibility and geometry. A reconstruction method was developed and evaluated in 19 patient MR examinations with ring applicator (plastic: 14, titanium: 5). MR applicator reconstruction uncertainties related to inter-observer variation were evaluated.Results: The catheters were visible in the plastic applicator on T1-weighted images in phantom and in 14/14 clinical applications. On T2-weighted images, the catheters appeared weaker but Still visible in phantom and in 13/14 MR clinical applications. In the titanium applicator, the catheters Could not be separated from the artifacts from the applicator itself. However, these artifacts could be used to localize both titanium ring applicator (5/5 clinical applications) and needles (6/6 clinical applications). Standard deviations of inter-observer differences were below 2 mm in all directions.Conclusion: 3D applicator reconstruction based on MR imaging Could be performed for plastic and titanium applicators. Plastic applicators proved well to be suited for MRI-based reconstruction. For improved practicability of titanium applicator reconstruction, development of MR applicator markets is essential. Reconstruction of titanium applicator and needles at 1.5 T MR requires geometric evaluations in phantoms before using the applicator in patients. (C) 2008 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 91 (2009) 187-193