Heparin prophylaxis for intraocular fibrin.
Heparin prophylaxis for intraocular fibrin.
复制标题
肝素预防眼内纤维蛋白。
DOI：
10.1016/s0161-6420(87)33403-7
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发表时间：
1987
期刊：
影响因子：
13.7
通讯作者：
Stern,WH
中科院分区：
文献类型：
--
作者：
Johnson,RN;Balyeat,E;Stern,WH
作者评价了肝素作为预防玻璃体切除和睫状体冷凝术后兔眼内纤维蛋白凝块形成的一种方法。此外，他们还研究了肝素输注对视网膜血管切开后眼内出血的影响。肝素有几种不同的给药途径。记录术后纤维蛋白凝块的范围，以及清除纤维蛋白凝块的天数。单次前房注射、补充肝素输液或单次静脉注射(IV)均导致术后眼内纤维蛋白显著减少。仅每天皮下注射一次并不能减少术后的纤维蛋白。术后无眼出血并发症发生。眼内持续输注10IU/cc的肝素并不改变视网膜血管切断后的出血时间。
The authors have evaluated the use of heparin as a method to prevent postoperative intraocular fibrin clot formation in the rabbit after vitrectomy and cyclocryotherapy. In addition, they have studied the effect of a heparin infusion on intraocular bleeding after sectioning of retinal vessels. Heparin was administered by several different routes. The extent of the postoperative fibrin clot, as well as the number of days until its clearing, were recorded. A single anterior chamber injection, heparin supplementation of the infusion solution, or a single intravenous (IV) injection, all resulted in a statistically significant reduction of postoperative intraocular fibrin. Once daily subcutaneous injections alone did not produce a reduction in postoperative fibrin. No ocular bleeding complications developed postoperatively. A constant heparin intraocular infusion of 10 IU/cc did not change the bleeding time after sectioning of a retinal vessel.