A stretchable and biodegradable strain and pressure sensor for orthopaedic application
A stretchable and biodegradable strain and pressure sensor for orthopaedic application
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DOI：
10.1038/s41928-018-0071-7
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发表时间：
2018-05-01
影响因子：
34.3
通讯作者：
Bao, Zhenan
中科院分区：
文献类型：
--
作者：
Boutry, Clementine M.;Kaizawa, Yukitoshi;Bao, Zhenan
能够实时监测手术修复后肌腱上的机械力，可以为康复患者制定个性化的康复方案。然而，由于对生物兼容材料的严格要求以及对具有令人满意的性能的传感器的需求，能够进行此类测量的设备的发展一直受到阻碍。在这里，我们报告了一种完全由可生物降解材料制成的植入式压力和应变传感器。传感器被设计成在其使用寿命之后退化，不需要进行第二次手术来移除设备。它可以使用两个垂直隔离的传感器来独立测量应变和压力，这些传感器能够区分小到0.4%的应变和一粒盐施加的压力(12Pa.)，它们不会相互干扰。该器件具有最小的滞后，响应时间在毫秒范围内，以及分别用于应变和压力传感的出色的循环稳定性。我们加入了一种可生物降解的弹性体，优化后将应变循环性能提高了54%。体内研究表明，该传感器在大鼠模型中表现出良好的生物兼容性和功能，说明该设备在肌腱愈合的实时监测中具有潜在的适用性。
The ability to monitor, in real time, the mechanical forces on tendons after surgical repair could allow personalized rehabilitation programmes to be developed for recovering patients. However, the development of devices capable of such measurements has been hindered by the strict requirements of biocompatible materials and the need for sensors with satisfactory performance. Here we report an implantable pressure and strain sensor made entirely of biodegradable materials. The sensor is designed to degrade after its useful lifetime, eliminating the need for a second surgery to remove the device. It can measure strain and pressure independently using two vertically isolated sensors capable of discriminating strain as small as 0.4% and the pressure exerted by a grain of salt (12 Pa), without them interfering with one another. The device has minimal hysteresis, a response time in the millisecond range, and an excellent cycling stability for strain and pressure sensing, respectively. We have incorporated a biodegradable elastomer optimized to improve the strain cycling performances by 54%. An in vivo study shows that the sensor exhibits excellent biocompatibility and function in a rat model, illustrating the potential applicability of the device to the real-time monitoring of tendon healing.