Nicotinamide Phosphoribosyl Transferase a Reliable Marker of Progression in Cervical Dysplasia.
Nicotinamide Phosphoribosyl Transferase a Reliable Marker of Progression in Cervical Dysplasia.
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DOI：
10.21873/anticanres.11889
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发表时间：
2017-09
影响因子：
2
通讯作者：
Shackelford R
中科院分区：
文献类型：
--
作者：
Vora M;Alattia LA;Ansari J;Ong M;Cotelingam J;Coppola D;Shackelford R
烟酰胺磷酸核糖转移酶（Nampt）催化哺乳动物烟酰胺腺嘌呤二核苷酸（NAD）补救途径的限速步骤。Nampt在几种上皮和间叶肿瘤中高度表达，促进细胞周期进展和化疗耐药性。据我们所知，Nampt表达的改变尚未在宫颈上皮内瘤变（CIN）或鳞状细胞癌（SCC）中检测到。我们使用组织芯片对14例良性宫颈鳞状上皮和15例CIN I，15例CIN II和13例CIN III样本进行了Nampt免疫组化分析。SCC包括5个低度恶性肿瘤、67个中度恶性肿瘤和81个高度恶性肿瘤。与良性宫颈鳞状上皮相比，Nampt水平随着CIN分级的增加而增加。同样，Nampt水平随着SCC等级的增加而增加。Nampt表达是宫颈不典型增生和SCC进展的可靠标志物。
Nicotinamide phosphoribosyl transferase (Nampt) catalyses the rate-limiting step of the mammalian nicotinamide adenine dinucleotide (NAD) salvage pathway. Nampt is highly expressed in several epithelial and mesenchymal neoplasms, where is promotes cell-cycle progression ans chemotherapy resistance. To our knowledge, alterations in Nampt expression have not been examined in cervical intraepithelial neoplasia (CIN) or squamous cell carcinoma (SCC). We performed immunohistochemical analysis for Nampt using tissue microarrays on 14 samples of benign cervical squamous epithelium and 15 CIN I, 15 CIN II, and 13 samples of CIN III. The SCCs included 5 low-grade, 67 intermediate-grade, and 81 high-grade tumors. Nampt levels increased with increased CIN grades were compared to benign cervical squamous epithelium. Similarly, Nampt levels increased with increasing SCC grade. Nampt expression is a reliable marker of progression in cervical dysplasia and SCC.
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影响因子：
37.3
作者：
Shukla S;Shishodia G;Mahata S;Hedau S;Pandey A;Bhambhani S;Batra S;Basir SF;Das BC;Bharti AC
通讯作者：
Bharti AC
影响因子：
--
作者：
Shackelford, Rodney E;Mayhall, Kim;Coppola, Domenico
通讯作者：
Coppola, Domenico
DOI：
10.1073/pnas.0505337102
发表时间：
2005-08-09
影响因子：
11.1
作者：
Huh, KW;DeMasi, J;Münger, K
通讯作者：
Münger, K
影响因子：
3.8
作者：
Kim, Jae Geun;Kim, Eun Ok;Lee, Byung Ju
通讯作者：
Lee, Byung Ju
影响因子：
2
作者：
Shackelford RE;Abdulsattar J;Wei EX;Cotelingam J;Coppola D;Herrera GA
通讯作者：
Herrera GA