Structures, functions, and mechanisms of filament forming enzymes: a renaissance of enzyme filamentation.
Structures, functions, and mechanisms of filament forming enzymes: a renaissance of enzyme filamentation.
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DOI：
10.1007/s12551-019-00602-6
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发表时间：
2019-12-01
影响因子：
--
通讯作者：
Horton, Nancy C
中科院分区：
文献类型：
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作者：
Park, Chad K;Horton, Nancy C
几十年来，人们已经知道非细胞骨架酶形成纤维，但直到最近才认识到其在酶调节和生物学中的广泛作用。这篇全面的综述总结了已知的每种酶在体外形成丝状结构，以及许多已知的仅在细胞内形成大的自组装体。对于一些酶，描述体外丝状结构和细胞自组装形成的研究也是已知的和描述的。特别注意每种类型的酶丝的详细结构，以及结构在酶调节和生物学中的作用。在已知或假设的情况下，对酶促反应所赋予的优点进行了综述。最后，SgrAI核酸内切酶系统的相似性，差异和比较也被强调。
Filament formation by non-cytoskeletal enzymes has been known for decades, yet only relatively recently has its wide-spread role in enzyme regulation and biology come to be appreciated. This comprehensive review summarizes what is known for each enzyme confirmed to form filamentous structures in vitro, and for the many that are known only to form large self-assemblies within cells. For some enzymes, studies describing both the in vitro filamentous structures and cellular self-assembly formation are also known and described. Special attention is paid to the detailed structures of each type of enzyme filament, as well as the roles the structures play in enzyme regulation and in biology. Where it is known or hypothesized, the advantages conferred by enzyme filamentation are reviewed. Finally, the similarities, differences, and comparison to the SgrAI endonuclease system are also highlighted.