Reverse-benzamidine antimalarial agents: Design, synthesis, and biological evaluation
Reverse-benzamidine antimalarial agents: Design, synthesis, and biological evaluation
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DOI：
10.1016/j.bmcl.2010.07.124
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发表时间：
2010-10-01
影响因子：
2.7
通讯作者：
Vo-Hoang, Yen
中科院分区：
文献类型：
--
作者：
Berger, Olivier;Wein, Sharon;Vo-Hoang, Yen
在双阳离子胆碱类似物开发的框架内，研究了双-N-烷基脒的RSA，并设计了一系列新的反向苯甲脒衍生物。与亲脂性相反，烷基脒化合物的碱性直接影响其抗疟功效。 (C) 2010 Elsevier Ltd. 保留所有权利。
In the frame of the development of bis-cationic choline analogs, the RSA of bis-N-alkylamidines were studied and a new series of reverse-benzamidine derivatives was designed. Contrary to the lipophilicity, the basicity of alkylamidine compounds directly influences their antimalarial potencies. (C) 2010 Elsevier Ltd. All rights reserved.