Biochemical and anatomical characterization of forepaw adjusting steps in rat models of Parkinson's disease: Studies on medial forebrain bundle and striatal lesions
Biochemical and anatomical characterization of forepaw adjusting steps in rat models of Parkinson's disease: Studies on medial forebrain bundle and striatal lesions
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DOI：
10.1016/s0306-4522(98)00217-6
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发表时间：
1999-01-01
期刊：
影响因子：
3.3
通讯作者：
Kang, UJ
中科院分区：
文献类型：
--
作者：
Chang, JW;Wachtel, SR;Kang, UJ
大鼠前爪调节步骤的缺陷已被提出作为与帕金森病相关的运动不能的非药物诱导模型。本研究探讨了对侧前爪调整步骤和多巴胺耗尽后内侧前脑束损伤与6-羟基多巴胺之间的关系。纹状体多巴胺消耗>80%导致大鼠调整步骤的能力急剧下降，但
Deficits in forepaw adjusting steps in rats have been proposed as a non-drug-induced model of the akinesia associated with Parkinson's disease. The present study examined the relationship between contralateral forepaw adjusting steps and dopamine depletion after medial forebrain bundle lesions with 6-hydroxydopamine. Depletion of striatal dopamine by >80% resulted in dramatic reductions in the ability of rats to make adjusting steps, but rats with