Site-specific functionalisation of proteins by a Staudinger-type reaction using unsymmetrical phosphites
Site-specific functionalisation of proteins by a Staudinger-type reaction using unsymmetrical phosphites
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DOI：
10.1039/b926818a
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发表时间：
2010-01-01
影响因子：
4.9
通讯作者：
Hackenberger, Christian P. R.
中科院分区：
文献类型：
--
作者：
Boehrsch, Verena;Serwa, Remigiusz;Hackenberger, Christian P. R.
不对称亚磷酸盐与对叠氮苯丙氨酸发生了有效的Staudinger反应，可用于蛋白质的生物素化反应，从而将芳基叠氮化合物与对称亚磷酸盐的化学选择性Staudinger-亚磷酸盐反应的范围扩大到相应的亚磷酸盐。
Unsymmetrical phosphites react efficiently in a Staudinger reaction with p-azido-phenylalanine, which can be applied for the biotinylation of proteins, thereby expanding the scope of the chemoselective Staudinger-phosphite reaction of aryl azides with symmetrical phosphites to the corresponding phosphoramidates.