Artificial water channels enable fast and selective water permeation through water-wire networks
Artificial water channels enable fast and selective water permeation through water-wire networks
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DOI：
10.1038/s41565-019-0586-8
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发表时间：
2019-12
影响因子：
38.3
通讯作者：
Woochul Song;Himanshu Joshi;Ratul Chowdhury;Joseph S. Najem;Yue-xiao Shen;Chao Lang;Codey B. Henderson;Yu-Ming Tu;Megan Farell;Megan E. Pitz;C. Maranas;P. Cremer;R. Hickey;Stephen A. Sarles;Jun‐Li Hou;A. Aksimentiev;Manish Kumar
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文献类型：
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作者：
Woochul Song;Himanshu Joshi;Ratul Chowdhury;Joseph S. Najem;Yue-xiao Shen;Chao Lang;Codey B. Henderson;Yu-Ming Tu;Megan Farell;Megan E. Pitz;C. Maranas;P. Cremer;R. Hickey;Stephen A. Sarles;Jun‐Li Hou;A. Aksimentiev;Manish Kumar
人工水通道是一种旨在模仿生物水通道结构和功能特征的合成分子（水通道蛋白）。本文报道了一种簇状有机纳米结构——多肽附加杂化[4]芳烃（PAH[4]），作为一类新的人工水道。荧光实验和模拟表明，多环芳烃可以通过横向扩散在脂质膜上形成簇，为水通过水丝网络的快速和选择性渗透提供协同跨膜路径。定量输运研究表明，多环芳烃[4]s每分子每秒可输运>109个水分子，与水通道蛋白水通道相当。从水/NaCl渗透率-选择性权衡曲线可以看出，这些通道的性能超过了现有脱盐膜的上限，高出了~104倍。多环芳烃b[4]通过协同水丝形成具有高水/溶质透性的独特特性，可以为分离、能源生产和屏障应用中的渗透膜材料带来另一种设计范式。
Artificial water channels are synthetic molecules that aim to mimic the structural and functional features of biological water channels (aquaporins). Here we report on a cluster-forming organic nanoarchitecture, peptide-appended hybrid[4]arene (PAH[4]), as a new class of artificial water channels. Fluorescence experiments and simulations demonstrated that PAH[4]s can form, through lateral diffusion, clusters in lipid membranes that provide synergistic membrane-spanning paths for a rapid and selective water permeation through water-wire networks. Quantitative transport studies revealed that PAH[4]s can transport >109water molecules per second per molecule, which is comparable to aquaporin water channels. The performance of these channels exceeds the upper bound limit of current desalination membranes by a factor of ~104, as illustrated by the water/NaCl permeability–selectivity trade-off curve. PAH[4]’s unique properties of a high water/solute permselectivity via cooperative water-wire formation could usher in an alternative design paradigm for permeable membrane materials in separations, energy production and barrier applications.