Abstinence-induced changes in self-report craving correlate with event-related fMRI responses to smoking cues
Abstinence-induced changes in self-report craving correlate with event-related fMRI responses to smoking cues
复制标题
DOI：
10.1038/sj.npp.1300780
复制
发表时间：
2005-10-01
影响因子：
7.6
通讯作者：
Rose, JE
中科院分区：
文献类型：
--
作者：
McClernon, FJ;Hiott, FB;Rose, JE
药物提示已经被证明可以激活成瘾者的大脑区域，这些区域涉及注意力，动机和奖励。然而，由于研究通常仅测量一种状态（即药物戒断）下的反应，因此尚不清楚观察到的激活是否代表戒断或稳定反应的扩增。因此，本研究的目的是评估依赖性吸烟者（n = 13）使用事件相关的功能磁共振成像措施的稳定性事件相关的反应视觉药物线索。成像进行后，像往常一样吸烟，并通宵戒烟，并获得自我报告的渴望措施之前，期间和之后的扫描。13个感兴趣区域的血流动力学反应（HDR）幅度分析显示，与腹侧前扣带回（vACG）和上级额回的对照线索相比，吸烟的反应更大。在这些区域和所有其他区域对吸烟提示的反应没有显示出禁欲/饱腹感的影响，从而支持了提示引起的大脑反应相对稳定的观点。然而，虽然禁欲操纵没有改变组水平的反应，吸烟线索，在个人层面上，禁欲引起的变化，渴望（禁欲减饱腹感）与HDR幅度的变化，以吸烟线索在额区，包括左额下回，左vACG，和双边额中回呈正相关。这些结果表明，大脑对吸烟线索的反应，虽然在短期戒烟后在群体水平上相对稳定，但可能会受到个体差异的调制，特别是在注意力和动机的区域。
Drug cues have been shown to activate brain regions involved in attention, motivation, and reward in addicted users. However, as studies have typically measured responses in only one state (ie drug abstinence), it is unclear whether observed activations represent amplification by abstinence or stable responses. Thus, the present study was designed to evaluate the stability of event-related responses to visual drug cues in dependent smokers (n = 13) using event-related functional magnetic resonance imaging measures. Imaging was conducted following smoking as usual and following overnight abstinence, and self-reported craving measures were obtained before, during, and after scanning. Analysis of hemodynamic response (HDR) amplitudes in each of 13 regions of interest revealed larger responses to smoking compared to control cues in ventral anterior cingulate gyrus (vACG) and superior frontal gyrus. Responses to smoking cues in these and all other regions revealed no effects of abstinence/ satiety, thus supporting the notion that cue-elicited brain responses are relatively stable. However, while the abstinence manipulation did not alter group-level responses to smoking cues, at the individual level, abstinence-induced changes in craving ( abstinence minus satiety) were positively correlated with changes in HDR amplitude to smoking cues in frontal regions including left inferior frontal gyrus, left vACG, and bilateral middle frontal gyrus. These results suggest that brain responses to smoking cues, while relatively stable at the group level following short-term abstinence, may be modulated by individual differences in craving in response to abstinence-particularly in regions subserving attention and motivation.