The use of 'top-up' experiments to investigate the effect of very small doses per fraction in mouse skin.
The use of 'top-up' experiments to investigate the effect of very small doses per fraction in mouse skin.
复制标题
使用“补充”实验来研究每个部分的极小剂量对小鼠皮肤的影响。
DOI：
10.1080/09553008514552811
复制
发表时间：
1986
期刊：
影响因子：
--
通讯作者：
R. Maughan
中科院分区：
文献类型：
--
作者：
M. Joiner;J. Denekamp;R. Maughan
部分公差类型的“充值”实验已被调查，以确定这种方法的分辨率研究小鼠皮肤的损伤，从非常小的剂量的X射线和中子。如果使用3 MeV中子作为“补充”参考辐射，则可以检测到20个部分的影响，每个部分小至0.10戈伊的X射线或0.05戈伊的中子。这一能力来自于低能中子的几乎线性的潜在剂量-反应曲线和高度可重复的剂量-效应关系。数据拟合的线性二次模型的剂量分级为X射线下降到0.75戈伊的分数剂量，但在较低的剂量有增加的趋势，在皮肤辐射敏感性。建模表明，这可能与显示出异常放射敏感性的细胞亚群一致，并且在小剂量分数之间的8小时内发生该亚群的补充。需要在非常低的剂量下进行更多的实验，以证实皮肤和其他组织的这一假设。
The partial tolerance type of 'top-up' experiment has been investigated to determine the resolution of this approach for studying the damage to mouse skin from very small doses of X-rays and neutrons. The effect of 20 fractions, each as small as 0.10 Gy of X-rays or of 0.05 Gy of neutrons, can be detected if 3 MeV neutrons are used as the 'top-up' reference radiation. This capability results from the almost linear underlying dose-response curve and highly reproducible dose-effect relationship for the low energy neutrons. The data fit the linear quadratic model of dose fractionation for X-rays down to fractional doses of 0.75 Gy, but at lower doses there is a trend towards an increase in the skin radiosensitivity. Modelling shows that this might be consistent with a sub-population of the cells showing an exceptional radiosensitivity, and a replenishment of this subpopulation occurring in the 8 h between small dose fractions. More experiments are needed at very low doses in order to confirm this hypothesis for skin and for other tissues.
弯曲剂量：有效分割的低剂量限度。
DOI：
10.1016/0360-3016(83)90270-5
发表时间：
1983
期刊：
International journal of radiation oncology, biology, physics
影响因子：
--
作者：
Tucker,SL;ThamesJr,HD
通讯作者：
ThamesJr,HD