Identification of two gene variants associated with risk of advanced fibrosis in patients with chronic hepatitis C
Identification of two gene variants associated with risk of advanced fibrosis in patients with chronic hepatitis C
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DOI：
10.1053/j.gastro.2006.02.032
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发表时间：
2006-05-01
期刊：
影响因子：
29.4
通讯作者：
Wright, Teresa L.
中科院分区：
文献类型：
--
作者：
Huang, Hongjin;Shiffman, Mitchell L.;Wright, Teresa L.
背景和目标：以前确定的临床风险因素，如性别，饮酒和感染时的年龄不能准确预测哪些慢性丙型肝炎（CHC）患者将发展为晚期纤维化（桥接纤维化和肝硬化）。本研究的目的是确定遗传多态性，可以预测晚期纤维化的风险与CHC患者。方法：共9：16例CHC患者从2个中心，一个基因为中心的疾病关联研究的24,832个假定的功能，单核苷酸多态性（SNPs）进行。在1609个显著相关（P
Background & Aims: Previously identified clinical risk factors such as sex, alcohol consumption, and age at infection do not accurately predict which patients with chronic hepatitis C (CHC) will develop advanced fibrosis (bridging fibrosis and cirrhosis). The aim of this study was to identify genetic polymorphisms that can predict the risk of advanced fibrosis in patients with CHC.Methods: A total of 9:16 subjects with CHC was enrolled from 2 centers, A gene-centric disease association study of 24,832 putative functional, single nucleotide polymorphisms (SNPs) was performed. Of the 1609 SNPs that were significantly associated (P