Pluripotent stem cells in regenerative medicine: challenges and recent progress.
Pluripotent stem cells in regenerative medicine: challenges and recent progress.
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DOI：
10.1038/nrg3563
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发表时间：
2014-02
期刊：
影响因子：
--
通讯作者：
Studer L
中科院分区：
文献类型：
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作者：
Tabar V;Studer L
经过多年的渐进式进展，最近的几项研究已经成功地从人类多能干细胞（hPSC）来源中获得疾病相关的细胞类型。无限细胞来源的前景，结合有希望的临床前数据，表明hPSC技术可能即将进入临床转化。在这篇综述中，我们讨论了定向分化的最新进展，一些促进hPSC疗法成功的新技术，以及开发基于hPSC的细胞疗法的道路上仍然存在的障碍。
After years of incremental progress, several recent studies have succeeded in deriving disease-relevant cell types from human pluripotent stem cell (hPSC) sources. The prospect of an unlimited cell source, combined with promising preclinical data, indicates that hPSC technology may be on the verge of clinical translation. In this Review, we discuss recent progress in directed differentiation, some of the new technologies that have facilitated the success of hPSC therapies and the remaining hurdles on the road towards developing hPSC-based cell therapies.