Assessment of the American Joint Commission on Cancer 8th Edition Staging System for Patients with Pancreatic Neuroendocrine Tumors: A Surveillance, Epidemiology, and End Results analysis.
Assessment of the American Joint Commission on Cancer 8th Edition Staging System for Patients with Pancreatic Neuroendocrine Tumors: A Surveillance, Epidemiology, and End Results analysis.
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美国癌症联合委员会第八版胰腺神经内分泌肿瘤患者分期系统的评估：监测、流行病学和最终结果分析。
DOI：
10.1002/cam4.1336
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发表时间：
2018-03
期刊：
影响因子：
4
通讯作者：
Wang C
中科院分区：
文献类型：
--
作者：
Li X;Gou S;Liu Z;Ye Z;Wang C
虽然已经提出了几种胰腺神经内分泌肿瘤（pNET）的分期系统，最佳分期系统仍不清楚。在这里，我们的目的是评估应用新修订的第8版美国癌症联合委员会（AJCC）分期系统外分泌胰腺癌（EPC）pNET，与其他分期系统相比。我们从监测，流行病学和最终结果（SEER）数据库（2004-2014）中确定了pNET患者。使用Kaplan-Meier曲线和对数秩检验分析总生存期。通过一致性指数（c-index）评估每个分期系统的预测准确性。采用考克斯比例风险回归分析计算不同阶段的影响。总共有2424例pNET患者，包括2350例接受切除术的患者，使用SEER数据进行了识别。根据第8版AJCC EPC分期系统对不同分期的患者进行均匀分层。Kaplan-Meier曲线在所有患者和使用第8版AJCC EPC分期系统切除的患者中分离良好。此外，风险比随着疾病分期的恶化而增加。第8版AJCC EPC分期系统的c指数与其他系统相似。对于pNETs患者，第8版AJCC EPC分期系统在所有患者和切除患者的不同分期之间显示出良好的预后区分。
Although several staging systems have been proposed for pancreatic neuroendocrine tumors (pNETs), the optimal staging system remains unclear. Here, we aimed to assess the application of the newly revised 8th edition American Joint Committee on Cancer (AJCC) staging system for exocrine pancreatic carcinoma (EPC) to pNETs, in comparison with that of other staging systems. We identified pNETs patients from the Surveillance, Epidemiology, and End Results (SEER) database (2004–2014). Overall survival was analyzed using Kaplan–Meier curves with the log‐rank test. The predictive accuracy of each staging system was assessed by the concordance index (c‐index). Cox proportional hazards regression was conducted to calculate the impact of different stages. In total, 2424 patients with pNETs, including 2350 who underwent resection, were identified using SEER data. Patients with different stages were evenly stratified based on the 8th edition AJCC staging system for EPC. Kaplan–Meier curves were well separated in all patients and patients with resection using the 8th edition AJCC staging system for EPC. Moreover, the hazard ratio increased with worsening disease stage. The c‐index of the 8th edition AJCC staging system for EPC was similar to that of the other systems. For pNETs patients, the 8th edition AJCC staging system for EPC exhibits good prognostic discrimination among different stages in both all patients and those with resection.
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美国癌症联合委员会多机构验证研究（第 8 版）胰腺癌患者 T 和 N 分期的变化。
影响因子：
9
作者：
Allen PJ;Kuk D;Castillo CF;Basturk O;Wolfgang CL;Cameron JL;Lillemoe KD;Ferrone CR;Morales-Oyarvide V;He J;Weiss MJ;Hruban RH;Gönen M;Klimstra DS;Mino-Kenudson M
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Mino-Kenudson M
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影响因子：
2.6
作者：
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通讯作者：
Frilling, A.
影响因子：
4.1
作者：
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通讯作者：
Oberg, K.