Colloidal metallic gold is not bio-inert
Colloidal metallic gold is not bio-inert
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DOI：
10.1007/s10787-007-0017-6
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发表时间：
2008-06-01
影响因子：
5.8
通讯作者：
Bushell, G. R.
中科院分区：
文献类型：
--
作者：
Brown, C. L.;Whitehouse, M. W.;Bushell, G. R.
金属金（Au度）是单价金Au（I）的可能生物转化产物，无论何时它与体内配体解离，Au度通过生物还原或通过自发歧化（与三价金的共同生产）形成。本文综述了胶体金属金（CMG）纳米颗粒的制备及其生物学相关性质。廷德尔紫是一种很好表征的CMG制剂，在大鼠中显示出有效的抗关节炎活性，约为金硫代苹果酸钠（Myocrysin）的10（3）倍。更值得注意的是，与这种经典的DMARD相比，它在大鼠中的作用范围更广。
Metallic gold (Au degrees) is a likely biotransformation product of monovalent gold, Au(I) whenever it is dissociated from in vivo ligands, Au degrees being formed either by bioreduction or by spontaneous dismutation (with co-production of trivalent gold). This review discusses the preparation and some biologically relevant properties of colloidal metallic gold (CMG) in its nano-particulate form. Tyndall's purple, a well characterised preparation of CMG, shows potent anti-arthritic activity in rats, approximately 10(3) times that of sodium aurothiomalate (Myocrysin). Even more remarkable is its broader spectrum of action in rats compared to this classic DMARD.