Transcriptional Regulation of the First Cell Fate Decision.
Transcriptional Regulation of the First Cell Fate Decision.
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发表时间：
2017
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通讯作者：
Catherine Rhee;Jonghwan Kim;Haley O. Tucker
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作者：
Catherine Rhee;Jonghwan Kim;Haley O. Tucker
了解第一个细胞命运决定是如何选择的是一个令人着迷的生物学问题，在过去十年中受到了人们的广泛关注。需要许多转录因子，并且许多转录因子已被证明在此过程中具有重要作用。在这里，我们重新研究转录因子主要在小鼠中发挥的功能——在此过程中对模型系统进行了最彻底的研究。我们讨论了第一个胚胎谱系是如何建立和维持的，特别强调随后的滋养外胚层发育以及最近建立的 Arid3a 转录因子在此过程中的作用。此外，我们回顾了胚胎干细胞重编程为滋养层干细胞（相当于外胚层（内细胞团））的相关方面，以及诱导滋养层干细胞（相当于滋养外胚层的体外相当于）的建立。
Understanding how the first cell fate decision has chosen is a fascinating biological question that was received consider attention over the last decade. Numerous transcription factors are required, and many have been shown to have essential roles in this process. Here we reexamine the function that transcription factors play primarily in the mouse-the model system most thoroughly examined in this process. We address how the first embryonic lineage is established and maintained, with a particular emphasis on subsequent trophectoderm development and the role of the recently established Arid3a transcription factor in this process. In addition, we review relevant aspects of embryonic stem cell reprogramming into trophoblast stem cells -the equivalent of the epiblast (inner cell mass) and the establishment of induced trophoblast stem cells-the in vitro equivalent of the trophectoderm.