Vitamin K suppresses lipopolysaccharide-induced inflammation in the rat
Vitamin K suppresses lipopolysaccharide-induced inflammation in the rat
复制标题
DOI：
10.1271/bbb.70.926
复制
发表时间：
2006-04-01
影响因子：
1.6
通讯作者：
Komai, M
中科院分区：
文献类型：
--
作者：
Ohsaki, Y;Shirakawa, H;Komai, M
维生素K（K）是哺乳动物血液凝固和骨代谢所必需的。K在从谷氨酸残基翻译后合成γ-羧基谷氨酸中充当辅因子。除肝脏和骨骼外，K还存在于大脑、心脏、肾脏和性腺组织中。然而，K在这些不同器官中的生理作用尚未完全了解。很可能K除了作为蛋白质γ-谷氨酰羧化的辅因子之外还有其他功能。在这项研究中，我们使用的DNA微阵列技术，以确定在大鼠肝脏中的基因表达的K状态的影响。与对照组和K-1补充饮食组相比，缺钾饮食组大鼠中参与急性炎症反应的基因表达增强。此外，膳食补充钾，抑制脂多糖管理引起的炎症。这些结果表明，口服给予K-1抑制了大鼠的炎症。
Vitamin K (K) is essential for blood coagulation and bone metabolism in mammals. K acts as a cofactor in the posttranslational synthesis of gamma-carboxyglutamic acid from glutamic acid residues. In addition to the liver and bone, K is found in the brain, heart, kidney and gonadal tissue. However, the physiological role of K in these various organs is not yet fully understood. It is likely that K has functions other than its role as a cofactor of protein gamma-glutamyl carboxylation. We used in this study the DNA microarray technique to identify the effect of K status on gene expression in the rat liver. The expression of genes involved in the acute inflammation response was enhanced in rats fed with a K-deficient diet relative to the control and K-1-supplemented diet groups. Moreover, dietary supplementation with K, suppressed the inflammation induced by lipopolysaccharide administration. These results indicate that orally administrated K-1 suppressed inflammation in the rat.