Coriander fruit exhibits gut modulatory, blood pressure lowering and diuretic activities
Coriander fruit exhibits gut modulatory, blood pressure lowering and diuretic activities
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DOI：
10.1016/j.jep.2008.12.016
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发表时间：
2009-02-25
影响因子：
5.4
通讯作者：
Gilani, Anwar H.
中科院分区：
文献类型：
--
作者：
Jabeen, Qaiser;Bashir, Samra;Gilani, Anwar H.
本研究的目的：香菜(Coriandrum Sativum)传统上用于治疗各种胃肠和心血管疾病，本研究旨在合理地将其用于治疗消化不良、腹痛、腹泻、高血压和利尿剂。材料和方法：通过体外和体内技术对香菜粗提物进行评价。结果：香菜粗提物在0.1-10 mg/ml的豚鼠回肠中对阿托品具有敏感的兴奋作用。在兔空肠标本上，Cs.Cr可引起类似的收缩反应，但在阿托品存在下，它对自发性和高K+(80 MM)引起的收缩均表现出松弛作用，并使钙浓度-反应曲线右移，与维拉帕米的作用相似。Cs.Cr(1-30 mg/ml)可引起麻醉动物动脉血压下降，并可被阿托品部分阻断。Cs.Cr对苯肾上腺素和K+(80 MM)引起的兔主动脉收缩有明显的血管扩张作用，对豚鼠的心房有明显的心脏抑制作用。Cs.Cr1-10 mg/kg对大鼠有利尿作用。生物测定定向分离结果显示，水提物和有机提要物中分别含有致痉挛和解痉剂成分。结论：香菜果实具有肠道刺激、抑制和降压作用，可能分别通过胆碱能、钙拮抗剂和这三种机制的结合发挥作用。利尿剂的活性增加了它在高血压中的应用价值。(C)2008爱思唯尔爱尔兰有限公司。保留所有权利。
Aim of the study: Coriander (Coriandrum sativum) is traditionally used for various gastrointestinal and cardiovascular disorders and this study was designed to rationalize its use in dyspepsia abdominal colic,, diarrhea, hypertension and as diuretic.Materials and methods: Coriander crude extract (Cs.Cr) was evaluated through in vitro and in vivo techniques.Results: Cs.Cr caused atropine sensitive stimulatory effect in isolated guinea-pig ileum (0.1-10 mg/ml). In rabbit jejunum preparations, Cs.Cr evoked a similar contractile response but in the presence of atropine, it exhibited relaxation against both spontaneous and high K+ (80 mM)-induced contractions as well as shifted the Ca2+ concentration-response curves to right, similar to that caused by verapamil. Cs.Cr (1-30 mg/ml) caused fall in arterial blood pressure of anesthetized animals, partially blocked by atropine. Cs.Cr produced vasodilatation against phenylephrine and K+ (80 mM)-induced contractions in rabbit aorta and cardio-depressant effect in guinea-pig atria. Cs.Cr produced diuresis in rats at 1-10 mg/kg. Bio-assay-directed fractionation revealed the separation of spasmogenic and spasmolytic components in the aqueous and organic fractions respectively.Conclusions: These results indicate that coriander fruit exhibits gut stimulatory, inhibitory and hypotensive effects mediating possibly through cholinergic, Ca2+ antagonist and the combination of these mechanisms respectively. Diuretic activity adds value to its use in hypertension. (C) 2008 Elsevier Ireland Ltd. All rights reserved.