Functional asymmetry in human primary auditory cortex: identified from longitudinal fMRI study.
Functional asymmetry in human primary auditory cortex: identified from longitudinal fMRI study.
复制标题
人类初级听觉皮层的功能不对称：从纵向功能磁共振成像研究中确定。
DOI：
10.1016/j.neulet.2005.03.025
复制
发表时间：
2005
影响因子：
2.5
通讯作者：
Panych,LawrenceP
中科院分区：
文献类型：
--
作者：
Yoo,Seung-Schik;O'leary,HeatherM;Dickey,ChandleeC;Wei,XingChang;Guttmann,CharlesRG;Park,HyunWook;Panych,LawrenceP
左半球在语言处理中的优势可能与初级听觉皮层（PAC）的基本功能不对称有关。基于重复功能磁共振成像（fMRI）测量，我们使用双耳语言声音（双音节名词）和简单的音调刺激来研究人类PAC中功能不对称的存在。8名右撇子志愿者接受了9次功能磁共振成像，间隔大约8周，持续时间超过一年。每个半球的PAC被人工分割，在分割的感兴趣区域内检测到的激活量在受试者和会话中被测量，以产生功能侧性指数。尽管会话和受试者之间的激活量存在差异，但我们发现在语言和非语言声音刺激期间，PAC的左侧功能不对称占主导地位且一致。
The leftward hemispheric dominance in language processing may be associated with fundamental functional asymmetry in the primary auditory cortex (PAC). Based on repeated functional MRI (fMRI) measurements, we investigated the presence of functional asymmetry in the human PAC using binaural presentation of linguistic sounds (two-syllable nouns) and simple tonal stimulation. Eight right-handed volunteers underwent nine fMRI sessions, approximately eight weeks apart, spanning the duration of more than a year. The PAC from each hemisphere was manually segmented and the volume of activation, detected within the segmented region-of-interest, was measured across the subjects and sessions to generate functional laterality indices. Although variations existed in activation volume between sessions and subjects, we found predominant and consistent leftward functional asymmetry in PAC during both linguistic and non-linguistic sound stimulations.