Suspected Lonely Mouse Syndrome as a Cage Effect in a Drug Safety Study.
Suspected Lonely Mouse Syndrome as a Cage Effect in a Drug Safety Study.
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DOI：
10.1155/2018/9562803
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
Guarnieri M
中科院分区：
文献类型：
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作者：
Ye X;Itzoe M;Sarabia-Estrada R;DeTolla L;Tyler BM;Guarnieri M
研究表明，丁丙诺啡，兽药镇痛的一线药物，可以缓解慢性疼痛的症状。采用笼侧观察法记录丁丙诺啡缓释小鼠临床试验中的行为体征。对观察到的疼痛和压力迹象的回顾性回顾显示，给予5倍过量丁丙诺啡（16.25 mg/kg）的小鼠表现出嗜睡和与压力相关的面部症状。然而，在无药对照小鼠中，早在单笼住房的第3天就观察到类似的迹象。这似乎是兽药临床试验中首次报道笼效应。
Studies have demonstrated that buprenorphine, a front line drug for veterinary analgesia, may alleviate symptoms of chronic pain. A cage side observation protocol was used to record behavioral signs in a mouse clinical trial of extended release buprenorphine. A retrospective review of the observations for signs of pain and stress revealed that mice given a fivefold overdose of buprenorphine (16.25 mg/kg) showed lethargy and facial signs associated with stress. However, similar signs were observed in the drug-free control mice as early as Day 3 of single-cage housing. This appears to be the first report of cage effects in a clinical trial for a veterinary drug.