Augmentation of left ventricular apical endocardial rotation with inotropic stimulation contributes to increased left ventricular torsion and radial strain in normal subjects - Quantitative assessment utilizing a novel automated tissue tracking technique
Augmentation of left ventricular apical endocardial rotation with inotropic stimulation contributes to increased left ventricular torsion and radial strain in normal subjects - Quantitative assessment utilizing a novel automated tissue tracking technique
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DOI：
10.1253/circj.71.661
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发表时间：
2007-05-01
影响因子：
3.3
通讯作者：
Matsuzaki, Masunori
中科院分区：
文献类型：
--
作者：
Akagawa, Eizo;Murata, Kazuya;Matsuzaki, Masunori
研究背景左室心内膜和心外膜扭转的差异。变力性刺激及其与径向应变（RS）的关系尚不清楚。方法和结果记录了13名正常受试者在休息时和多巴酚丁胺输注期间（5，10 μ g中心点kg（-1）中心点min（-1））的LV基底和心尖短轴图像。采用二维组织追踪技术，在心内膜和心外膜上分别手动定位前、侧、后、间隔共8个点，追踪每个心动周期内各点的运动，计算旋转角度和RS。LV扭转定义为基底旋转和心尖旋转之间的净差值。多巴酚丁胺组左室心尖部的内旋增加（7.8 ± 2.7至14.1 ± 4.6度，p < 0.01），而外旋无变化。心尖内旋显著大于外旋，尽管在整个研究期间，在LV基底的Endo和Epi之间未观察到差异。在多巴酚丁胺输注期间，左心室内扭转增加（9.5 +/- 2.8至19.3 +/- 4.8度，p < 0.01），这些值大于Epi。心尖部RS随多巴酚丁胺剂量增加而增加（39.0 +/- 9.3至61.9 +/-15.5%，p < 0.01），而基础RS最初在5 μ g中心点kg（-1）中心点min（-1）时增加，但此后在10 μ g中心点kg（-1）中心点min（-1）时没有进一步增加结论左室心尖部心内膜明显增强左室旋转，并具有变力性，从而导致左室内径扭转和心尖部RS增加。
Background The difference in the left ventricular (LV) torsion of the endo- and epicardium (Endo, Epi) with. inotropic stimulation and its relation to radial strain (RS) remain unclear.Methods and Results LV basal and apical short-axis images were recorded in 13 normal subjects at rest and during dobutamine infusion (5, 10 mu g center dot kg(-1)center dot min(-1)). A total of 8 points (anterior, lateral, posterior and septum in both Endo and Epi) were manually placed by 2-dimensional tissue tracking technique and the movement of these points during a cardiac cycle was tracked, after which the rotation angles and RS were calculated. LV torsion was defined as the net difference between the basal and apical rotations. In the LV apex, Endo-rotation increased (7.8 +/- 2.7 to 14.1 +/- 4.6 degrees, p < 0.01), whereas Epi-rotation was unchanged, with dobutamine. The apical Endorotation was significantly greater than the Epi-rotation, although no difference was seen between the Endo and Epi in the LV base throughout the study. During dobutamine infusion, the LV Endo-torsion increased (9.5 +/- 2.8 to 19.3 +/- 4.8 degrees, p < 0.01) and these values were greater than those for Epi. The apical RS increased with the dobutamine dose (39.0 +/- 9.3 to 61.9 +/- 15.5%, p < 0.01), whereas basal RS initially increased at 5 mu g center dot kg(-1)center dot min(-1), but thereafter showed no further increase at 10 mu g center dot kg(-1)center dot min(-1) of dobutamine.Conclusions Augmentation of LV rotation with inotropism was clearly observed in the apical Endo, thus causing increased LV endo-torsion and apical RS.