Hepatitis B in an oncology unit.
Hepatitis B in an oncology unit.
复制标题
肿瘤科的乙型肝炎。
DOI：
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发表时间：
1974
影响因子：
158.5
通讯作者：
C. C. Carpenter
中科院分区：
文献类型：
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作者：
J. Wands;J. Walker;T. Davis;L. Waterbury;A. Owens;C. C. Carpenter
摘要 在一个肿瘤科工作的91名人员中，有9人发生了严重的乙型肝炎感染。在疫情期间，另外8名在疫情前已有乙型肝炎表面抗体（抗 - HBs）的人员，其抗 - HBs滴度升高了4倍或更多，似乎免受了乙型肝炎疾病的侵害。当11名员工出现从抗 - HBs阴性到阳性的血清转化时，无症状的乙型肝炎表面抗原（HBs Ag）暴露变得明显。在疫情前、疫情期间和疫情后，在87名肿瘤患者中检测到19.5%的HBs Ag频率。在5名已有HBs Ag的无症状患者中，在高剂量抗肿瘤化疗时出现了异常高的HBs Ag滴度（平均为1:128,000），其中一名患者可能是8名工作人员的共同感染源。无症状和无黄疸的HBs Ag阳性肿瘤患者对肿瘤科工作人员构成很大风险，应采取预防措施。（《新英格兰医学杂志》291:1371 - 1375，...
Abstract In nine of 91 personnel working in an oncology unit serious hepatitis-B infection developed. Eight others with pre-existing hepatitis-B surface antibody (anti-HBs) before the epidemic showed a fourfold or greater rise in anti-HBs titer during the epidemic and appeared protected from the hepatitis-B illness. Asymptomatic hepatitis-B surface antigen (HBs Ag) exposure became apparent when seroconversion from anti-HBs negative to positive was noted in 11 employees. A 19.5 per cent frequency of HBs Ag was detected in 87 patients with tumor before, during and after the epidemic. In five asymptomatic patients with pre-existing HBs Ag, unusually high HBs Ag titers (mean, 1:128,000) developed on high dose antitumor chemotherapy, and one of these patients may have served as a common source exposure for eight personnel. Asymptomatic and anicteric HBs Ag-positive patients with tumor represent a great risk to oncology-unit personnel, and prophylactic measures should be instituted. (N Engl J Med 291:1371–1375,...