Inflammation and EMT: an alliance towards organ fibrosis and cancer progression.
Inflammation and EMT: an alliance towards organ fibrosis and cancer progression.
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DOI：
10.1002/emmm.200900043
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发表时间：
2009-09
影响因子：
11.1
通讯作者：
Angela Nieto, M.
中科院分区：
文献类型：
--
作者：
Miguel Lopez-Novoa, Jose;Angela Nieto, M.
我们对控制炎症与器官纤维化和癌症相关性的分子途径的理解的最新进展指出，上皮细胞向间质细胞转化（EMT）是这些破坏性疾病进展的共同联系。EMT是胚胎中不同组织发育的关键过程，其在成人中的重新激活可被视为控制炎症反应和“治愈”受损组织的生理尝试。然而，在病理学背景下，如肿瘤或器官纤维化的发展过程中，这种愈合反应具有险恶的性质，将这些疾病引向转移和器官衰竭。重要的是，纤维化和癌细胞共同的慢性炎症微环境成为诱导病理性EMT的决定性因素。
Recent advances in our understanding of the molecular pathways that govern the association of inflammation with organ fibrosis and cancer point to the epithelial to mesenchymal transition (EMT) as the common link in the progression of these devastating diseases. The EMT is a crucial process in the development of different tissues in the embryo and its reactivation in the adult may be regarded as a physiological attempt to control inflammatory responses and to ‘heal’ damaged tissue. However, in pathological contexts such as in tumours or during the development of organ fibrosis, this healing response adopts a sinister nature, steering these diseases towards metastasis and organ failure. Importantly, the chronic inflammatory microenvironment common to fibrotic and cancer cells emerges as a decisive factor in the induction of the pathological EMT.
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DOI：
10.1007/s12306-008-0064-1
发表时间：
2008-12-01
期刊：
La Chirurgia degli organi di movimento
影响因子：
--
作者：
Devescovi, Valentina;Leonardi, Elisa;Cenni, Elisabetta
通讯作者：
Cenni, Elisabetta
影响因子：
13.2
作者：
DIAMOND, JR
通讯作者：
DIAMOND, JR
影响因子：
50.3
作者：
Bruna, Alejandra;Darken, Rachel S.;Seoane, Joan
通讯作者：
Seoane, Joan
影响因子：
8
作者：
Chua, H. L.;Bhat-Nakshatri, P.;Nakshatri, H.
通讯作者：
Nakshatri, H.
影响因子：
64.5
作者：
Adorno, Maddalena;Cordenonsi, Michelangelo;Piccolo, Stefano
通讯作者：
Piccolo, Stefano