The course of Plasmodium chabaudi chabaudi infections in interferon-gamma receptor deficient mice
The course of Plasmodium chabaudi chabaudi infections in interferon-gamma receptor deficient mice
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DOI：
10.1046/j.1365-3024.1997.d01-227.x
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发表时间：
1997-08-01
影响因子：
2.2
通讯作者：
Rudin, W
中科院分区：
文献类型：
--
作者：
Favre, N;Ryffel, B;Rudin, W
用血液期查鲍迪疟原虫寄生的干扰素-γ受体(干扰素-γR)缺陷小鼠，观察干扰素-γ的抗疟疾作用。在寄生虫血症的第一个高峰期间，两种类型的小鼠的寄生虫血症无显著差异。然而，干扰素-γR缺陷小鼠表现出白细胞增加和高死亡率，而所有野生型小鼠在第一次寄生虫血症后9-11天出现明显的第二次寄生虫血症高峰，寄生虫血症与死亡率高达65%。此外，血清一氧化氮(NO)水平仅在寄生虫血症高峰期在野生型小鼠中发现，而在干扰素-γR缺陷小鼠中保持在背景水平。与野生型小鼠相比，干扰素-γR缺陷小鼠的寄生虫特异性抗体产生没有显著差异。此外，野生型和干扰素-γR缺陷小鼠在再次感染时都得到了同等的保护。这些结果表明保护性免疫的发展延迟，并暗示在感染的最初三周内，干扰素-γR在控制血液期疟疾方面起着至关重要的作用。
Interferon-gamma receptor (IFN-gamma R) deficient mice parasitized with blood-stage Plasmodium chabaudi chabaudi were used to assess the anti-malarial activity of interferon-gamma (IFN-gamma). There was no significant difference in the parasitaemia between the two types of mice during the first peak of parasitaemia. However, IFN-gamma R deficient mice displayed an increased leucocytosis and a high mortality rate, whereas all of the wild type mice, developed a pronounced second parasitaemia peak, 9 to 11 days after the first one, with a parasitaemia of up to 65% associated with mortality. Furthermore, increased serum levels of nitric oxide (NO) were only found in wild type mice at the peak of parasitaemia, whereas it remained at background levels in IFN-gamma R deficient mice. Parasite-specific antibody production was not significantly different in IFN-gamma R deficient mice, as compared to wild type mice. In addition, both wild type and IFN-gamma R deficient mice were equally protected upon reinfection. These results indicate a delayed development of protective immunity and imply a crucial function for the IFN-gamma R in the control of blood stage malaria during the initial three weeks of infection.