Influence of iron and zinc status on cadmium accumulation in Bangladeshi women
Influence of iron and zinc status on cadmium accumulation in Bangladeshi women
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DOI：
10.1016/j.taap.2007.04.009
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发表时间：
2007-07-15
影响因子：
3.8
通讯作者：
Vahter, Marie
中科院分区：
文献类型：
--
作者：
Kippler, Maria;Ekstrom, Eva-Charlotte;Vahter, Marie
镉是一种广泛存在于食品中的环境污染物。铁储量低的人肠道吸收增加，但锌缺乏的影响尚不清楚。本研究的目的是评估铁和锌状况对孟加拉国孕妇镉积累的影响。我们使用电感耦合等离子体光谱法（ICPMS）测量了890名妇女尿液中的镉。此外，我们还测定了血浆中铁蛋白和锌的含量。尿中镉浓度中位数为0.59 μ g/L（调整为平均比重1.012 g/mL）。协方差分析（ANCOVA）表明，尿镉与血浆铁蛋白和血浆锌之间存在显著的相互作用。该分析根据年龄和社会经济地位进行了调整。铁储量低且锌含量充足的女性尿镉含量明显高于铁储量和锌含量都充足的女性。铁和锌含量低的女性与铁和锌含量充足的女性相比，尿镉含量没有差异。总之，铁储量低与镉积累增加有关。但只有在锌充足的情况下。(C) 2007爱思唯尔公司版权所有。
Cadmium is a widespread environmental contaminant present in food. The absorption in the intestine increases in individuals with low iron stores, but the effect of zinc deficiency is not clear. The aim of the present study was to assess the influence of iron and zinc status on cadmium accumulation in pregnant Bangladeshi women. We measured cadmium in urine from 890 women using inductively coupled plasma rnass spectrometry (ICPMS). Further, we also measured ferritin and zinc in plasma. The median cadmium concentration in urine was 0.59 mu g/L (adjusted to mean specific gravity of 1.012 g/mL). Analysis of covariance (ANCOVA) showed that urinary cadmium was associated with plasma ferritin and plasma zinc via a significant interaction between dichotomized plasma ferritin and plasma zinc. The analysis was adjusted for age and socioeconomic status. Women with low iron stores and adequate zinc status had significantly higher urinary cadmium compared to women with both adequate iron stores and zinc status. There was no difference in urinary cadmium between women with both low iron stores and zinc status compared to those with both adequate iron stores and zinc status. In conclusion, low iron stores were associated with increased cadmium accumulation. but only at adequate zinc status. (C) 2007 Elsevier Inc. All rights reserved.