Computational multiscale modeling in the UPS physiome project: Modeling cardiac electromechanics
Computational multiscale modeling in the UPS physiome project: Modeling cardiac electromechanics
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DOI：
10.1147/rd.506.0617
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发表时间：
2006-11-01
影响因子：
1.3
通讯作者：
Hunter, P.
中科院分区：
文献类型：
--
作者：
Nickerson, D.;Nash, M.;Hunter, P.
我们提出了一个计算建模和数值模拟框架，使多个物理和时空尺度的生理系统模型的集成。该框架是IUPS（国际生理科学联合会）生理组计划的基础。一个新颖的方面是使用CellML，注释的数学表示语言，指定模型和仿真特定的方程。在细胞，组织和器官的空间尺度的心脏电动力学模型概述，以说明框架的发展和实施。我们量化的计算需求进行模拟，使用这样的模型和比较模型的不同生物物理细节。其他生理系统的应用也进行了讨论。
We present a computational modeling and numerical simulation framework that enables the integration of multiple physics and spatiotemporal scales in models of physiological systems. This framework is the foundation of the IUPS (International Union of Physiological Sciences) Physiome Project. One novel aspect is the use of CellML, an annotated mathematical representation language, to specify model- and simulation-specific equations. Models of cardiac electromechanics at the cellular, tissue, and organ spatial scales are outlined to illustrate the development and implementation of the framework. We quantify the computational demands of performing simulations using such models and compare models of differing biophysical detail. Applications to other physiological systems are also discussed.