High sensitivity of in vivo detection of gold nanorods using a laser optoacoustic imaging system
High sensitivity of in vivo detection of gold nanorods using a laser optoacoustic imaging system
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DOI：
10.1021/nl070557d
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发表时间：
2007-07-01
期刊：
影响因子：
10.8
通讯作者：
Motamedi, Massoud
中科院分区：
文献类型：
--
作者：
Eghtedari, Mohammad;Oraevsky, Alexander;Motamedi, Massoud
激光光声成像系统（LOIS）造影剂的开发可以显着扩大这种成像方式在早期检测癌性肿瘤方面的临床前和临床应用。金纳米棒被设计用来增强光声成像的对比度。在体内条件下，将25 μ L浓度为1.25 pM的金纳米棒溶液注射到裸鼠体内，用单通道声换能器检测。皮下注射100 μ L的金纳米颗粒溶液，用LOIS观察125 pM时金纳米颗粒在体内的分布情况。我们的研究结果表明，LOIS可以用于低浓度金纳米棒的体内检测，并且可以对纳米颗粒进行改造以提高光声成像的诊断能力。
The development of a contrast agent for a laser optoacoustic imaging system (LOIS) can significantly widen preclinical and clinical applications of this imaging modality for early detection of cancerous tumors. Gold nanorods were engineered to enhance the contrast for optoacoustic imaging. Under in vivo conditions, 25 mu L of gold nanorods solution at a concentration of 1.25 pM were injected into nude mice and detected using a single-channel acoustic transducer. LOIS was used to visualize the distribution of gold nanoparticles at a concentration of 125 pM in vivo when 100 mu L of solution of gold nanoparticles was delivered subcutaneously. Our results suggest that LOIS can be used for in vivo detection of gold nanorods at low concentrations and the nanoparticles can be engineered to enhance the diagnostic power of optoacoustic imaging.