Genomic associations with bill length and disease reveal drift and selection across island bird populations.
Genomic associations with bill length and disease reveal drift and selection across island bird populations.
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DOI：
10.1002/evl3.38
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发表时间：
2018-03
影响因子：
5
通讯作者：
Spurgin LG
中科院分区：
文献类型：
--
作者：
Armstrong C;Richardson DS;Hipperson H;Horsburgh GJ;Küpper C;Percival-Alwyn L;Clark M;Burke T;Spurgin LG
岛屿物种提供了很好的模式，调查如何选择和漂移在野生种群，并确定这些过程如何影响当地的适应和物种形成。在这里，我们研究的作用，选择和漂移在塑造基因组和表型变异在最近分离的种群的伯塞洛的pipit（Anthus berthelotii），雀形目鸟类特有的三个群岛在大西洋。我们首先描述了遗传多样性和人口结构，支持以前的推断，最近的殖民和瓶颈的历史。然后，我们测试了与喙长和疟疾感染等生态学重要特征相关的基因组区域，这两个特征在该物种的种群中差异很大。我们确定了一个SNP与个体，岛屿和群岛之间的法案长度的变化;在这个SNP的变化模式表明，在法案长度的表型和基因型变异主要是由创始人的影响。疟疾与参与免疫反应的基因附近/内部的SNP相关，但这种关系在群岛之间并不一致，支持抗病性复杂且快速进化的观点。虽然我们发现很少的证据表明，在候选位点的法案长度和疟疾抗性的分歧选择，基因组扫描分析指出，几个相关的免疫和代谢基因在分歧和适应的重要作用。我们的研究结果强调了在非平衡群体中结合关联作图和群体遗传分析的实用性和挑战，以解开漂移和选择对塑造基因型和表型的影响。
Island species provide excellent models for investigating how selection and drift operate in wild populations, and for determining how these processes act to influence local adaptation and speciation. Here, we examine the role of selection and drift in shaping genomic and phenotypic variation across recently separated populations of Berthelot's pipit (Anthus berthelotii), a passerine bird endemic to three archipelagos in the Atlantic. We first characterized genetic diversity and population structuring that supported previous inferences of a history of recent colonizations and bottlenecks. We then tested for regions of the genome associated with the ecologically important traits of bill length and malaria infection, both of which vary substantially across populations in this species. We identified a SNP associated with variation in bill length among individuals, islands, and archipelagos; patterns of variation at this SNP suggest that both phenotypic and genotypic variation in bill length is largely shaped by founder effects. Malaria was associated with SNPs near/within genes involved in the immune response, but this relationship was not consistent among archipelagos, supporting the view that disease resistance is complex and rapidly evolving. Although we found little evidence for divergent selection at candidate loci for bill length and malaria resistance, genome scan analyses pointed to several genes related to immunity and metabolism as having important roles in divergence and adaptation. Our findings highlight the utility and challenges involved with combining association mapping and population genetic analysis in nonequilibrium populations, to disentangle the effects of drift and selection on shaping genotypes and phenotypes.
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影响因子：
9.8
作者：
Akey JM;Eberle MA;Rieder MJ;Carlson CS;Shriver MD;Nickerson DA;Kruglyak L
通讯作者：
Kruglyak L
影响因子：
3.7
作者：
Baird NA;Etter PD;Atwood TS;Currey MC;Shiver AL;Lewis ZA;Selker EU;Cresko WA;Johnson EA
通讯作者：
Johnson EA
影响因子：
9.2
作者：
Chang CC;Chow CC;Tellier LC;Vattikuti S;Purcell SM;Lee JJ
通讯作者：
Lee JJ
影响因子：
4.9
作者：
Corander, Jukka;Majander, Kerttu K.;Merila, Juha
通讯作者：
Merila, Juha
影响因子：
3
作者：
Alexander DH;Lange K
通讯作者：
Lange K