Perivascular fat-mediated vascular dysfunction and remodeling through the AMPK/mTOR pathway in high-fat diet-induced obese rats
Perivascular fat-mediated vascular dysfunction and remodeling through the AMPK/mTOR pathway in high-fat diet-induced obese rats
复制标题
DOI：
10.1038/hr.2010.11
复制
发表时间：
2010-05-01
影响因子：
5.4
通讯作者：
Zhu, Zhiming
中科院分区：
文献类型：
--
作者：
Ma, Liqun;Ma, Shuangtao;Zhu, Zhiming
血管周围脂肪组织（PVAT）参与生理状态下血管功能的调节，但在肥胖过程中PVAT对血管的调节作用知之甚少。内皮型一氧化氮合酶（eNOS）、腺苷酸活化蛋白激酶（AMPK）和哺乳动物雷帕霉素靶蛋白（mTOR）参与血管功能的调节。因此，我们研究了PVAT是否通过AMPK/mTOR通路在肥胖相关的血管功能障碍中发挥潜在作用。与普通饲料喂养的大鼠相比，高脂饮食喂养6个月的Wistar大鼠的主动脉周围脂肪量更高（3.31 +/- 0.56 vs. 2.34 +/- 0.28 g，P
Perivascular adipose tissue (PVAT) is implicated in the regulation of vascular function in the physiological state, but the modulatory effect of PVAT on vasculature during obesity is poorly understood. Endothelial nitric oxide synthase (eNOS), AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) participate in the regulation of vascular function. We therefore investigated whether PVAT has a potential role through the AMPK/mTOR pathway in obesity-related vascular dysfunction. Wistar rats on a high-fat diet (HFD) for 6 months had higher periaortic fat mass compared with rats on a chow diet (3.31 +/- 0.56 vs. 2.34 +/- 0.28 g, P