Microtubules and actin filaments: dynamic targets for cancer chemotherapy
Microtubules and actin filaments: dynamic targets for cancer chemotherapy
复制标题
DOI：
10.1016/s0955-0674(98)80095-1
复制
发表时间：
1998-02-01
影响因子：
7.5
通讯作者：
Wilson, L
中科院分区：
文献类型：
--
作者：
Jordan, MA;Wilson, L
微管和肌动蛋白丝在有丝分裂、细胞信号传导和运动中起重要作用。因此，这些细胞骨架细丝是越来越多的抗癌药物的目标。本文综述了目前对这些药物与微管和肌动蛋白丝聚合的机制和动力学的认识。此外，我们概述了如何通过靶向微管，药物通过在有丝分裂检查点阻断有丝分裂并诱导细胞凋亡来抑制细胞增殖。本文还讨论了新型抗癌药物的β -微管蛋白同型特异性以及作用于肌动蛋白细胞骨架的药物的抗肿瘤潜力。
Microtubules and actin filaments play important roles in mitosis, cell signaling, and motility. Thus these cytoskeletal filaments are the targets of a growing number of anti-cancer drugs. In this review we summarize the current understanding of the mechanisms of these drugs in relation to microtubule and actin filament polymerization and dynamics. In addition, we outline how, by targeting microtubules, drugs inhibit cell proliferation by blocking mitosis at the mitotic checkpoint and inducing apoptosis. The beta-tubulin isotype specificities of new anticancer drugs and the antitumor potential of agents that act on the actin cytoskeleton are also discussed.