A Layman's Guide to High‐Resolution Mass Spectrometry
A Layman's Guide to High‐Resolution Mass Spectrometry
复制标题
高分辨率质谱分析外行指南
DOI：
10.1002/awwa.1480
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发表时间：
2020
期刊：
影响因子：
0.7
通讯作者：
Hanigan, David
中科院分区：
文献类型：
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作者：
McKenna, Elizabeth;Sharma, Priyamvada;McCurry, Daniel L.;Hanigan, David
娱乐行业让公众相信，科学家能够从任何东西中提取样本，并迅速识别出可能存在的特定有毒物质。广受欢迎的电视节目《犯罪现场调查》（Crime Scene Investigation）包括一个（灯光昏暗的）法医实验室，它能迅速对血液或其他随机溶液中的化学物质和毒物做出明确的鉴定。直到最近，能够在其他有机化合物的复杂混合物中识别出一种未知的化合物基本上是一种谬论。然而，高分辨率质谱法（HRMS）的广泛采用已经允许识别未知的有毒物质，使小说更接近现实。虽然HRMS已经在成千上万的出版物中使用，但最近一个与水有关的例子是来自西雅图华盛顿大学的爱德华·科洛兹耶的实验室，它遵循了犯罪现场调查的概念。Kolodziej的研究小组在降雨期间采集了导致银鲑死亡的城市雨水样本。利用HRMS，研究人员确定了在风暴事件和径流来源中共同发生的有机化学物质，表明从轮胎磨损颗粒中浸出的有机化学物质可能是导致鳕鱼死亡的原因（https://doi）。org/10.1021/acs。美国东部时间8 b03287)。
The entertainment industry has led the public to believe that scientists are able to take a sample of anything and quickly identify specific toxicants that might be present. The popular television show Crime Scene Investigation includes a (darkly lit) forensics lab that quickly produces unequivocal identification of chemicals and poisons in blood or other random solutions. Until relatively recently, being able to identify an unknown compound in a complex mixture of other organic compounds was mostly a fallacy. However, the wider adoption of high-resolution mass spectrometry (HRMS) has permitted identification of unknown toxicants, bringing fiction closer to reality.Although HRMS has been used in thousands of publications, one recent water-related example that follows the Crime Scene Investigation concept comes from the lab of Edward Kolodziej at the University of Washington, Seattle. Kolodziej’s research group took samples of urban stormwater during rain events that resulted in coho salmon fish kills. Using HRMS, the researchers identified organic chemicals that co-occurred in storm events and runoff sources, showing that organic chemicals leaching from tire wear particles were a likely cause of the coho salmon mortality (https://doi. org/10.1021/acs. est. 8b03287).
DOI：
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发表时间：
1978
期刊：
影响因子：
--
作者：
A. R. Trussell;Mark D. Umphres
通讯作者：
Mark D. Umphres