Synthesis of Quinazoline and Quinazolinone Derivatives via Ligand-Promoted Ruthenium-Catalyzed Dehydrogenative and Deaminative Coupling Reaction of 2-Aminophenyl Ketones and 2-Aminobenzamides with Amines
Synthesis of Quinazoline and Quinazolinone Derivatives via Ligand-Promoted Ruthenium-Catalyzed Dehydrogenative and Deaminative Coupling Reaction of 2-Aminophenyl Ketones and 2-Aminobenzamides with Amines
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DOI：
10.1021/acs.orglett.9b01082
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发表时间：
2019-05-03
期刊：
影响因子：
5.2
通讯作者：
Yi, Chae S.
中科院分区：
文献类型：
--
作者：
Arachchige, Pandula T. Kirinde;Yi, Chae S.
发现原位形成的钌催化体系（[Ru]/L）对2-氨基苯基酮与胺的缩合偶联反应具有高选择性。2-氨基苯甲酰胺与胺的脱氨基偶联反应导致喹唑啉酮产物的有效形成。该催化偶联方法提供了喹唑啉和喹唑啉酮衍生物的有效合成，而不使用任何反应性试剂或形成任何有毒副产物。
The in situ formed ruthenium catalytic system ([Ru]/L) was found to be highly selective for the dehydrogenative coupling reaction of 2-aminophenyl ketones with amines to form quinazoline products. The deaminative coupling reaction of 2-aminobenzamides with amines led to the efficient formation of quinazolinone products. The catalytic coupling method provides an efficient synthesis of quinazoline and quinazolinone derivatives without using any reactive reagents or forming any toxic byproducts.