Suppression of L-histidine decarboxylase mRNA expression by methyleugenol
Suppression of L-histidine decarboxylase mRNA expression by methyleugenol
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DOI：
10.1006/bbrc.1997.6260
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发表时间：
1997-03-06
影响因子：
3.1
通讯作者：
Kim, HM
中科院分区：
文献类型：
--
作者：
Shin, BK;Lee, EH;Kim, HM
我们研究了甲基丁香酚对过敏反应的影响。甲基丁香酚完全抑制化合物48/80诱导的小鼠全身过敏反应。甲基丁香酚还抑制抗二硝基苯基（DNP）IgE激活的局部过敏反应。此外，甲基丁香酚剂量依赖性地抑制由化合物48/80或抗DNP IgE激活的肥大细胞中的组胺释放。Northern-blot分析表明，显着降低水平的L-组氨酸脱羧酶（HDC）的mRNA表达的肥大细胞与甲基丁香酚，相比，没有甲基丁香酚。结论：甲基丁香酚直接影响肥大细胞组胺释放和HDC基因过表达。(C)北京：科学出版社.
We investigated the effect of methyleugenol on anaphylaxis. Methyleugenol completely inhibited systemic anaphylaxis induced by compound 48/80 in mice. Methyleugenol also inhibited local anaphylaxis activated by anti-dinitrophenyl (DNP) IgE. Moreover, methyleugenol dose-dependently inhibited histamine release in mast cells activated by compound 48/80 or anti-DNP IgE. Northern-blot analysis demonstrated that significantly reduced level of the mRNA of L-histidine decarboxylase (HDC) was expressed in mast cells treated with methyleugenol, compared to that without methyleugenol. We conclude that methyleugenol directly affect histamine release and HDC gene over-expression in mast cells. (C) 1997 Academic Press.