Retinal processing of intrinsic ad extrinsic noise.
Retinal processing of intrinsic ad extrinsic noise.
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视网膜处理内在和外在噪声。
DOI：
10.1152/jn.1982.48.4.992
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发表时间：
1982
影响因子：
2.5
通讯作者：
M. Levine
中科院分区：
文献类型：
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作者：
M. Levine
1.从金鱼离体视网膜中的单个神经节细胞进行记录。在黑暗中，在存在基本上局限于感受野中心的稳定适应光的情况下，以及在存在由高斯白色噪声调制的相同适应光的情况下，计算稳态放电的维持放电的统计。2.稳定的适应灯影响了发射率的显着初始变化，并影响了测试探头的灵敏度。然而，在新的一分钟后，速率恢复到中等水平。有没有一致的关系，在黑暗和照明条件下发射，也没有一致的关系，在黑暗中发射的变异系数的值之间的关系，并在光，虽然一些个别的细胞显示这些属性的变化时，照明。3.在黑暗和稳定的光线下，射击的组织没有一致的变化。无论是标准化的自协方差，也不是串行相关图，短期秩序的指标，显着影响光。同样，标准差的速度与样本持续时间，长期结构的指标，绘图没有改变照明。因此，固有噪声似乎不受视网膜照明的影响。4.高斯调制的适应光（非本征噪声）增加了变异系数，它也大大增加了平均放电率。这种效应在红开和红关细胞中都观察到;它表明即使在空间线性X样神经元中也存在非线性。5.适应光的高斯调制使得归一化自协方差的短持续时间值稍微更正。类似地，调制使串行相关图的前两个或三个系数更正;这表明对外部噪声进行了低通滤波。6.适应光的高斯调制对速率与样本持续时间的标准差的图没有影响，除了由于增加的可变性而引起的简单平移。由于在没有调制的情况下这些曲线的形式意味着对固有噪声进行高通滤波，因此也必须通过相同（或类似）的高通滤波器来处理非固有噪声。7.提出了一个模型，其中外部信号的带通滤波器的低通和高通滤波器级联。在维持放电中明显的固有可变性明显地注入两个过滤器之间。替代的可能性进行了讨论。
1. Recordings were made from single ganglion cells in the isolated retinas of goldfish. Statistics of the maintained discharge were computed for steady-state firing in the dark, in the presence of a steady-adapting light confined essentially to the center of the receptive field, and in the presence of the same adapting light modulated by Gaussian white noise. 2. Steady adapting lights effected a significant initial change in firing rate and affected sensitivities to test probes. After a new minutes, however, the rate returned to a moderate level. There was no consistent relationship between firing in the dark and illuminated conditions, nor was there a consistent relationship between the values of the coefficient of variation of firing in the dark and in light, although some individual cells showed changes in these properties when illuminated. 3. There was no consistent change in the organization of the firing in dark and in steady light. Neither the normalized autocovariances nor the serial correlograms, indicators of short-term order, were significantly affected by light. Similarly, plots of the standard deviation of rate versus sample duration, an indicator of long-term structure, were not altered by illumination. The intrinsic noise thus appears unaffected by retinal illumination. 4. Gaussian modulation of an adapting light (extrinsic noise) increased the coefficient of variation; it also dramatically increased mean firing rate. This effect was observed in both red-on and red-off cells; it indicates a nonlinearity that is present even in the spatially linear X-like neurons. 5. Gaussian modulation of an adapting light made the short-duration values of the normalized autocovariances slightly more positive. Similarly, modulation made the first two or three coefficients of the serial correlogram more positive; this indicates low pass filtering of the extrinsic noise. 6. Gaussian modulation of an adapting light had no effect on the plots of standard deviation of rate versus sample duration other than simple translation due to increased variability. Since the form of these plots in the absence of modulation implies high-pass filtering of the intrinsic noise, the extrinsic noise must also be processed by the same (or a similar) high-pass filter. 7. A model is proposed in which extrinsic signals are band pass filtered by a low-pass and a high-pass filter in cascade. The intrinsic variability evident in the maintained discharge is apparently injected between the two filters. Alternative possibilities are discussed.