Direct interhemispheric cortical communication via thalamic commissures: a new white-matter pathway in the primate brain.
Direct interhemispheric cortical communication via thalamic commissures: a new white-matter pathway in the primate brain.
复制标题
通过丘脑连合的直接半球间皮质通讯：灵长类动物大脑中的新白质通路。
DOI：
10.1101/2023.06.15.545128
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Le
中科院分区：
文献类型：
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作者：
Szczupak,Diego;Schaeffer,DavidJ;Tian,Xiaoguang;Choi,Sang-Ho;Fang-Cheng;Iack,PamelaMeneses;Campos,ViniciusP;Mayo,JPatrick;Patsch,Janina;Mitter,Christian;Haboosheh,Amit;Vieira,MarceloAC;Kasprian,Gregor;Tovar-Moll,Fernanda;Le
真兽类哺乳动物的皮质神经元投射到对侧半球，主要通过胼胝体以及前、后和海马连合穿过中线。我们最近报道并命名丘脑连合（TC）作为啮齿动物大脑中连接皮层和对侧丘脑的额外半球间轴突纤维通路。在这里，我们证明 TC 也存在于灵长类动物中，并通过高分辨率扩散加权 MRI、病毒轴突追踪和功能磁共振成像来表征这些通路的连接性。我们提供了新世界（Callithrix jacchusandCebus apella）和旧世界灵长类动物（Macaca mulatta）中存在 TC 的证据。此外，与啮齿类动物一样，我们发现灵长类动物的 TC 在胚胎期发育，形成皮质与对侧丘脑的解剖学和功能上活跃的连接。我们还在人脑中寻找 TC，结果显示它们存在于大脑畸形的人类中，尽管我们无法在健康受试者中识别 TC。这些结果表明 TC 是灵长类动物大脑中的重要纤维通路，允许更强大的半球间连接和同步性，并作为发育性大脑畸形的替代连合路径。
Cortical neurons of eutherian mammals project to the contralateral hemisphere, crossing the midline primarily via the corpus callosum and the anterior, posterior, and hippocampal commissures. We recently reported and named the thalamic commissures (TCs) as an additional interhemispheric axonal fiber pathway connecting the cortex to the contralateral thalamus in the rodent brain. Here, we demonstrate that TCs also exist in primates and characterize the connectivity of these pathways with high-resolution diffusion-weighted MRI, viral axonal tracing, and fMRI. We present evidence of TCs in both New World (Callithrix jacchusandCebus apella) and Old World primates (Macaca mulatta). Further, like rodents, we show that the TCs in primates develop during the embryonic period, forming anatomical and functionally active connections of the cortex with the contralateral thalamus. We also searched for TCs in the human brain, showing their presence in humans with brain malformations, although we could not identify TCs in healthy subjects. These results pose the TCs as a vital fiber pathway in the primate brain, allowing for more robust interhemispheric connectivity and synchrony and serving as an alternative commissural route in developmental brain malformations.