Highly concentrated vascular endothelial growth factor in platelets in Crow-Fukase syndrome
Highly concentrated vascular endothelial growth factor in platelets in Crow-Fukase syndrome
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DOI：
10.1002/1097-4598(200007)23:7
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发表时间：
2000-07-01
期刊：
影响因子：
3.4
通讯作者：
Osame, M
中科院分区：
文献类型：
--
作者：
Hashiguchi, T;Arimura, K;Osame, M
我们报告了血管内皮生长因子（VEGF）的浓度显着差异，血清和血浆中的Crow-crowase综合征（CFS）患者。4例CFS患者的血清/血浆VEGF水平分别为8，634/152、5，203/176、3，724/127和868/13 pg/ml。我们还发现，血小板是这种VEGF的主要来源，并且VEGF在血小板聚集过程中通过生理刺激释放。这表明，在CFS中，局部VEGF浓度显着升高的血小板聚集含有过量的VEGF和它们的粘附到血管壁，导致过度的生理活性的VEGF。我们的发现为开发更有效的治疗试验提供了重要信息。(C)John Wiley & Sons，Inc.
We report a marked difference in concentration of vascular endothelial growth factor (VEGF) between serum and plasma in patients with Crow-Fukase syndrome (CFS). The serum/plasma VEGF levels in 4 CFS patients were 8,634/152, 5,203/176, 3,724/127, and 868/13 pg/ml, respectively. We also showed that platelets were a major source of this VEGF and that VEGF was released during platelet aggregation by physiological stimulation. It is suggested that in CFS, local VEGF concentration is markedly elevated by aggregation of platelets containing excessive VEGF and their adhesion to vascular walls, resulting in excessive physiological activities of VEGF. Our findings provide important information for developing more effective therapeutic trials. (C) 2000 John Wiley & Sons, Inc.