A NONHUMAN PRIMATE MODEL FOR HUMAN CEREBRAL MALARIA - RHESUS-MONKEYS EXPERIMENTALLY INFECTED WITH PLASMODIUM FRAGILE
A NONHUMAN PRIMATE MODEL FOR HUMAN CEREBRAL MALARIA - RHESUS-MONKEYS EXPERIMENTALLY INFECTED WITH PLASMODIUM FRAGILE
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DOI：
10.1006/expr.1994.1040
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发表时间：
1994-06-01
影响因子：
2.1
通讯作者：
AIKAWA, M
中科院分区：
文献类型：
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作者：
FUJIOKA, H;MILLET, P;AIKAWA, M
我们研究了感染了灵长类疟原虫脆性疟原虫的恒河猴的大脑，电子显微镜显示，在这些动物中，感染了脆性疟原虫的红细胞会被隔离，并且寄生的红细胞通过旋钮粘附在脑微血管的内皮细胞上。免疫组织化学分析显示，具有隔离的寄生红细胞的脑微血管具有血小板糖蛋白CD36、血小板反应蛋白和细胞内粘附分子1。在脑微血管中也观察到玫瑰花结的形成。与人类脑型疟疾类似，脆弱疟原虫在动物体内产生神经系统症状。因此，感染脆性疟原虫的恒河猴，就像感染科氏疟原虫的猴子一样，可以用作研究人类脑型疟疾的灵长类动物模型。 (C) 1994 年学术出版社
We studied the brains of rhesus monkeys infected with the primate malaria parasite Plasmodium fragile, Electron microscopy showed that, in these animals, erythrocytes infected with P. fragile undergo sequestration and that parasitized red blood cells adhere to endothelial cells in the cerebral microvessels by means of knobs. Cerebral microvessels with sequestered parasitized red blood cells were shown by immunohistochemical analysis to possess the platelet glycoprotein CD36, thrombospondin, and intracellular adhesion molecule-1. The formation of rosettes also was observed in the cerebral microvessels. In a fashion similar to human cerebral malaria, P. fragile produced neurological symptoms in the animals. Thus, rhesus monkeys infected with P. fragile, like those monkeys infected with Plasmodium coatneyi, can be used as a primate model to study human cerebral malaria. (C) 1994 Academic Press, Inc.