FOXO transcription factors: key regulators of cell fate
FOXO transcription factors: key regulators of cell fate
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DOI：
10.1042/bst0340722
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发表时间：
2006-11-01
影响因子：
3.9
通讯作者：
Petkovic, M.
中科院分区：
文献类型：
--
作者：
Lam, E. W-F.;Francis, R. E.;Petkovic, M.
FOX0(Forkhead Box 0)转录因子是细胞命运的重要调节因子。FOX0蛋白的这种功能依赖于它们控制不同的、有时是相反的细胞功能的能力，如增殖、分化、DNA修复、防御氧化应激损伤和凋亡，以响应激素、生长因子和其他环境信号。这篇综述讨论了我们目前对FOX0转录因子在决定细胞命运中的调控和作用的理解，并强调了它们与肿瘤发生和耐药的相关性。
FOX0 (forkhead box 0) transcription factors are crucial regulators of cell fate. This function of FOX0 proteins relies on their ability to control diverse and at times, opposing cellular functions, such as proliferation, differentiation, DNA repair, defence against oxidative stress damage and apoptosis, in response to hormones, growth factors and other environmental cues. This review discusses our current understanding of the regulation and role of FOX0 transcription factors in determining cell fate and highlights their relevance to tumorigenesis and drug resistance.