Epidemiological survey of enterovirus infections occurring in Taiwan between 2000 and 2005: Analysis of sentinel physician surveillance data
Epidemiological survey of enterovirus infections occurring in Taiwan between 2000 and 2005: Analysis of sentinel physician surveillance data
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DOI：
10.1002/jmv.21006
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发表时间：
2007-12-01
影响因子：
12.7
通讯作者：
Wang, Jen-Ren
中科院分区：
文献类型：
--
作者：
Tseng, Fan-Chen;Huang, Han-Chin;Wang, Jen-Ren
肠病毒（EV）感染很常见。已知有60多种血清型，每种血清型具有不同的流行病学或医学重要性。来自台湾75%的基层行政单位的700多名医生参加了“传染病哨点医生监测”，每周向台湾疾病控制中心报告各种感染的数据。分析了2000年至2005年监测中实验室确诊的EV感染数据。通过免疫荧光染色和/或病毒VP1序列分析确定EV血清型。共发现12236例EV病例，即每年约1300 - 2500例，其中52%的病例发生在4月至7月期间。中位年龄为3岁，男性占57.6%。除2004年外，柯萨奇病毒A (CA) 16和EV71是每年最流行的血清型，主要表现为手足口病。其他流行的血清型和相关症状每年都有所不同。2001年和2002年流行与无菌性脑膜炎相关的埃可病毒(E) 30和E6, 2004年主要是引起疱疹性咽峡炎的CA4和CA10, 2004年和2005年最常见的分别是与新生儿发热性疾病相关的柯萨奇病毒B (CB) 4和CD3。其中一些流行与其他亚太国家相同血清型的暴发重叠。在所有血清型中，EV71型与患者严重并发症的发生率最高。调查各血清型EV的流行模式、疾病谱和严重程度为公共卫生和医务人员提供了重要信息。
Enterovirus (EV) infections are common. There are more than 60 known serotypes, and each has different epidemiologic or medical importance. Over 700 physicians from 75% of basic administrative units of Taiwan participated in the "Sentinel Physician Surveillance of Infectious Disease" and reported weekly to the Center for Disease Control-Taiwan with data on various infections. Data of laboratory-confirmed EV infections from this surveillance between 2000 and 2005 was analyzed. EV serotypes were determined by immunofluorescence staining and/or viral VP1 sequence analysis. A total of 12,236 EV cases, or approximately 1,300-2,500 per year, were identified, and 52% of the cases occurred between April and July. The median age was 3 years, and 57.6% of patients were male. Coxsackievirus A (CA) 16 and EV71, which primarily manifest as hand-foot-and-mouth disease, were the most prevalent serotypes every year except 2004. Other prevalent serotypes and associated symptoms varied from year to year. Echovirus (E) 30 and E6, which are associated with aseptic meningitis, were prevalent in 2001 and 2002, CA4 and CA10, which cause herpangina, were predominant in 2004, and coxsackievirus B (CB) 4 and CD3, which are associated with neonatal febrile disease, were most common in 2004 and 2005, respectively. Some of these epidemics overlapped with outbreaks of the same serotypes in other Asian Pacific countries. Of all serotypes, EV71 was associated with the highest number of severe complications in patients. Surveying the epidemic pattern, disease spectra, and severity associated with each EV serotype provided important information for public health and medical personnel.