Tolerance induced by chronic inhaled antigen in a murine asthma model is not mediated by endotoxin.
Tolerance induced by chronic inhaled antigen in a murine asthma model is not mediated by endotoxin.
复制标题
在小鼠哮喘模型中，慢性吸入抗原诱导的耐受性不是由内毒素介导的。
DOI：
10.1016/j.bbadis.2006.02.002
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Thrall,RS
中科院分区：
文献类型：
--
作者：
Schramm,CM;Guernsey,L;Secor,E;Thrall,RS
卵清蛋白（OVA）致敏的野生型（WT）和内毒素抗性（ER）小鼠在急性雾化OVA激发后，气道嗜酸性粒细胞增多和血清OVA特异性IgE水平相似。WT小鼠表现出乙酰甲胆碱高反应性，而ER小鼠的反应性没有变化。随着长期雾化OVA激发，WT和ER小鼠均产生了局部耐受性，气道嗜酸性粒细胞增多症消退，但血清中抗OVA IgE持续存在。因此，长期气雾剂暴露于OVA的局部耐受性的发展与OVA气雾剂溶液中内毒素的任何潜在影响无关。
Ovalbumin (OVA)-sensitized wildtype (WT) and endotoxin-resistant (ER) mice developed similar degrees of airways eosinophilia and serum OVA-specific IgE levels after acute aerosolized OVA challenge. WT mice demonstrated methacholine hyperreactivity, whereas ER mice showed no change in responsiveness. With chronic aerosolized OVA challenge, both WT and ER mice developed local tolerance, with resolution of airway eosinophilia but persistence of anti-OVA IgE in serum. Thus, the development of local tolerance with chronic aerosol exposure to OVA is independent of any potential effects of endotoxin in the OVA aerosol solution.