Ultrahigh sensitive optical microangiography for in vivo imaging of microcirculations within human skin tissue beds.
Ultrahigh sensitive optical microangiography for in vivo imaging of microcirculations within human skin tissue beds.
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DOI：
10.1364/oe.18.008220
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发表时间：
2010-04-12
期刊：
影响因子：
3.8
通讯作者：
Wang RK
中科院分区：
文献类型：
--
作者：
An L;Qin J;Wang RK
在本文中，我们首次证明，详细的皮肤血流在毛细血管水平的真皮内的人皮肤可以成像的光学微血管造影（OMAG）技术。采用快速B扫描模式实现了毛细血管血流成像。我们采用1310 nm系统，以每秒300帧的成像速率扫描皮肤组织，仅需0.5秒即可完成皮肤内毛细血管血流的一次3D成像。该技术足够灵敏，可以对0.4 μm/sec的非常缓慢的血流成像。这些令人鼓舞的结果显示了OMAG在人类皮肤疾病的诊断、治疗和管理中的巨大潜力。
In this paper, we demonstrate for the first time that the detailed cutaneous blood flow at capillary level within dermis of human skin can be imaged by optical micro-angiography (OMAG) technique. A novel scanning protocol, i.e. fast B scan mode is used to achieve the capillary flow imaging. We employ a 1310nm system to scan the skin tissue at an imaging rate of 300 frames per second, which requires only ∼5 sec to complete one 3D imaging of capillary blood flow within skin. The technique is sensitive enough to image the very slow blood flows at ∼4 μm/sec. The promising results show a great potential of OMAG's role in the diagnosis, treatment and management of human skin diseases.