Patterning of cortical efferent projections by semaphorin-neuropilin interactions
Patterning of cortical efferent projections by semaphorin-neuropilin interactions
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DOI：
10.1126/science.282.5395.1904
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发表时间：
1998-12-04
期刊：
影响因子：
56.9
通讯作者：
Ghosh, A
中科院分区：
文献类型：
--
作者：
Polleux, F;Giger, RJ;Ghosh, A
皮质神经元通过通过白质的固定轴突投射与不同的皮质和皮质下目标进行交流。切片叠加实验表明，皮质轴突向白质的初始生长受到位于边缘区域附近的可扩散化学排斥信号的调节。信号素III是这种可扩散信号的主要成分，皮质神经元通过神经毛细蛋白-1受体传递这一信号。这些观察表明，信号素-神经粘连蛋白的相互作用在发育中的皮质中最初的投射模式中起着关键作用。
Cortical neurons communicate with various cortical and subcortical targets by way of stereotyped axon projections through the white matter. Slice overlay experiments indicate that the initial growth of cortical axons toward the white matter is regulated by a diffusible chemorepulsive signal localized near the marginal zone. Semaphorin III is a major component of this diffusible signal, and cortical neurons transduce this signal by way of the neuropilin-1 receptor. These observations indicate that semaphorin-neuropilin interactions play a critical role in the initial patterning of projections in the developing cortex.