Short-Term Influence of Radiofrequency Ablation on NT-proBNP, MR-proANP, Copeptin, and MR-proADM in Patients With Atrial Fibrillation: Data From the Observational SMURF Study.
Short-Term Influence of Radiofrequency Ablation on NT-proBNP, MR-proANP, Copeptin, and MR-proADM in Patients With Atrial Fibrillation: Data From the Observational SMURF Study.
复制标题
射频消融对NT-ProBNP，MR-ProANP，Copeptin和Mr-Proadm对心房颤动患者的短期影响：观察性蓝精灵研究的数据。
DOI：
10.1161/jaha.116.003557
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发表时间：
2016-09-15
影响因子：
5.4
通讯作者：
Alehagen U
中科院分区：
文献类型：
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作者：
Charitakis E;Walfridsson H;Alehagen U
射频消融(RFA)对2种心脏生物标志物的短期影响知之甚少：N端心钠素前体(NT-proBNP)和心钠素前体N端中区片段(MR-proANP)和2个心外生物标志物；C端前加压素(Copeptin)和肾上腺髓质素前体(MR-proADM)。关于后两者的心脏产生的数据也是有限的。我们研究了连续192名有资格接受射频消融术的房颤患者，转诊到瑞典林肯平的大学医院。分别于消融前、消融后即刻和术后即刻、次日测定外周血、冠状静脉窦(CS)和左心房组织中NT-proBNP、MR-proANP、Copeptin和MR-proADM水平。射频消融时房颤患者的NT-ProBNP水平在射频消融后第二天降低，而窦性心律患者的血浆NT-ProBNP水平略有升高(P<；0.001)。此外，无论实际节律如何，MR-proANP水平在射频消融后立即升高(P<；0.001)，然后在消融后第二天下降(P<；0.001)。COP水平在射频消融术后立即显示为基线的6倍(P<；0.001)，而MR-proADM水平在射频消融术后第二天增加(P<；0.001)。与外周血相比，CS中的Copeptin和MR-proADM水平并不高。房颤的RFA是一种强烈的刺激，对不同的神经激素系统有显著和直接的影响。我们没有发现心脏释放MR-proADM或Copeptin的迹象。网址：http://www.clinicaltrials.gov.唯一标识：NCT01553045。
There is limited knowledge on the short‐term influence of radiofrequency ablation (RFA) of atrial fibrillation (AF) on 2 cardiac biomarkers; the N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) and the midregional fragment of the N‐terminal of pro‐ANP (MR‐proANP) and 2 extracardiac biomarkers; the c‐terminal provasopressin (copeptin) and the midregional portion of proadrenomedullin (MR‐proADM). There are also limited data concerning cardiac production of the latter two. We studied 192 consecutive patients eligible for RFA of AF referred to the University Hospital, Linköping, Sweden. NT‐proBNP, MR‐proANP, copeptin, and MR‐proADM levels were measured in peripheral blood, the coronary sinus (CS), and the left atrium before ablation, and in peripheral blood immediately and the day after RFA. The level of NT‐proBNP decreased the day after RFA in participants in AF at the time of RFA, compared to the participants in sinus rhythm who showed a slight increase (P<0.001). Furthermore, regardless of the actual rhythm, the level of MR‐proANP showed an increase immediately after RFA (P<0.001), followed by a decrease the day after ablation (P<0.001). Copeptin level showed a 6‐fold increase immediately after RFA compared to baseline (P<0.001), whereas MR‐proADM level increased the day after RFA (P<0.001). Levels of copeptin and MR‐proADM were not higher in the CS compared to peripheral blood. RFA of AF is a strong stimulus with a significant and direct impact on different neurohormonal systems. We found no sign of a cardiac release of MR‐proADM or copeptin. URL: http://www.clinicaltrials.gov. Unique Identifier: NCT01553045.