Bone as an endocrine organ.
Bone as an endocrine organ.
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DOI：
10.4158/ep12141.ra
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发表时间：
2012-09
期刊：
影响因子：
--
通讯作者：
Rosen CJ
中科院分区：
文献类型：
--
作者：
Guntur AR;Rosen CJ
骨通常被认为是一种惰性结构，对于运动性、钙稳态和维持造血生态位是必要的。在小鼠中使用复杂的遗传操作的骨生物学的最新进展突出了骨不仅作为支撑人体的结构支架，而且作为独立于矿物质代谢的许多代谢过程的调节剂的重要性。这些进展表明骨骼是一个内分泌器官，通过分泌骨特异性蛋白质骨钙素来调节葡萄糖耐量和睾酮的产生。这篇综述将详细介绍骨如何成为一个真正的内分泌“腺体”，并与此，潜在的治疗意义，可以实现这种骨分泌组织。
Bone has classically been viewed as an inert structure that is necessary for mobility, calcium homeostasis, and maintenance of the hematopoietic niche. Recent advances in bone biology using complex genetic manipulations in mice have highlighted the importance of bone not only as a structural scaffold to support the human body, but also as a regulator of a number of metabolic processes that are independent of mineral metabolism. These advances point to the skeleton as an endocrine organ that modulates glucose tolerance and testosterone production by secretion of a bone-specific protein, osteocalcin. This review will detail how bone has emerged as a bona-fide endocrine “gland”, and with that, the potential therapeutic implications that could be realized for this hormone-secreting tissue.